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Tmie
Gene Detail
Symbol

Name
ID
Tmie
transmembrane inner ear
MGI:2159400
Synonyms
5131400L21Rik, Mm.87012
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:110865711-110880113 bp, - strand
From VEGA annotation of GRCm38

  14403 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TMIE
Gene Tree: Tmie

Human
homologs
TMIE, transmembrane inner ear
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 259236
neXtProt AC: NX_Q8NEW7

Human Synonyms: DFNB6

Human Chr (Location): 3p21; chr3:46693842-46710923 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TMIE

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Spontaneous(4) Targeted(2)
Genomic Mutations involving Tmie (2)
 
Mutations in this gene cause circling behavior and deafness in homozygous mice.
 
Interactions
Tmie interacts with 132 markers (Mir26b, Mir92-2, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process inner ear morphogenesis, sensory perception of sound
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tmie    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021713 (Evidence)
Ensembl Gene Model ENSMUSG00000049555 (Evidence)
Entrez Gene 20776 (Evidence)
UniGene 390229
NIA Mouse Gene Index U031373
Consensus CDS Project CCDS23578.1
International Mouse Phenotyping Consortium Status Tmie
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021713 VEGA Gene Model | MGI Sequence Detail 14403 C57BL/6J ±  kb
transcript OTTMUST00000051525 VEGA | MGI Sequence Detail 2802 Not Applicable 
polypeptide OTTMUSP00000024269 VEGA | MGI Sequence Detail 153 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(18) UniProt(3)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016442 transmembrane inner ear expressed protein
References
(Earliest) J:13132 DEOL MS, et al., The spinner mouse. J Hered. 1962 May-Jun;53:133-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGD-MRK-14553, MGI:2443547, MGI:98395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory