About   Help   FAQ
Vangl1
Gene Detail
 Symbol
Name
ID
Vangl1
vang-like 1 (van gogh, Drosophila)
MGI:2159344
Synonyms KITENIN, Lpp2, mStbm, stbm
Feature Type protein coding gene
Genetic Map
Chromosome 3
44.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:102156701-102204693 bp, - strand
From VEGA annotation of GRCm38

  47993 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Vang-like protein
Gene Tree: Vangl1

Human
homologs
Human Homolog VANGL1, VANGL planar cell polarity protein 1
NCBI Gene ID 81839
neXtProt AC  NX_Q8TAA9
Human Synonyms  KITENIN, LPP2, STB2, STBM2
Human Chr (Location)  1p13.1; chr1:115641953-115698224 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human VANGL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(86) : Gene trapped(81) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Vangl1 interacts with 250 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process multicellular organismal development
Component integral component of membrane, lateral plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (47)    Tissues (46)   
Theiler Stages: 17, 20, 22, 25, 27, 28
Assay TypeResults
RNA in situ 47
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031053 (Evidence)
Ensembl Gene ModelENSMUSG00000027860 (Evidence)
Entrez Gene229658 (Evidence)
UniGene118004
DFCITC1583921, TC1614089
DoTSDT.101218170, DT.528024, DT.91348763, DT.97397300
NIA Mouse Gene IndexU118163
Consensus CDS ProjectCCDS17686.1, CCDS51024.1
International Mouse Knockout Project StatusVangl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031053 VEGA Gene Model | MGI Sequence Detail 47993 C57BL/6J ±  kb
transcript OTTMUST00000076931 VEGA | MGI Sequence Detail 3413 Not Applicable 
polypeptide OTTMUSP00000040562 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(334 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009539 Strabismus
Protein Ontology PR:000017255 Vang-like protein 1
References (Earliest) J:70272 Kibar Z, et al., Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5
(Latest) J:206576 Fukuda T, et al., Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory