Vangl1
Gene Detail

Symbol

Name
ID

Vangl1
vang-like 1 (van gogh, Drosophila)
MGI:2159344

Synonyms

KITENIN, Lpp2, mStbm, stbm

Feature Type

protein coding gene

Genetic Map

Chromosome 3
44.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:102156701-102204693 bp, - strand From VEGA annotation of GRCm38   47993 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:44540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Vang-like protein
Gene Tree: Vangl1

Human
homologs

Human Homolog		VANGL1, VANGL planar cell polarity protein 1
NCBI Gene ID		81839
neXtProt AC		NX_Q8TAA9
Human Synonyms		KITENIN, LPP2, STB2, STBM2
Human Chr (Location)		1p13.1; chr1:115641953-115698224 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human VANGL1

Mutations,
alleles, and
phenotypes

All mutations/alleles(86) : Gene trapped(81) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities.

 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)

Interactions

Vangl1 interacts with 250 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (7 annotations)

Process	multicellular organismal development
Component	integral component of membrane, lateral plasma membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (17 records)

Data Summary: Results (47)    Tissues (46)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	47

cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000031053 (Evidence)
Ensembl Gene Model	ENSMUSG00000027860 (Evidence)
Entrez Gene	229658 (Evidence)
UniGene	118004
DFCI	TC1614089, TC1583921
DoTS	DT.97397300, DT.91348763, DT.528024, DT.101218170
NIA Mouse Gene Index	U118163
Consensus CDS Project	CCDS17686.1, CCDS51024.1
International Mouse Knockout Project Status	Vangl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031053	VEGA Gene Model | MGI Sequence Detail	47993	C57BL/6J
transcript	OTTMUST00000076931	VEGA | MGI Sequence Detail	3413	Not Applicable
polypeptide	OTTMUSP00000040562	VEGA | MGI Sequence Detail	526	Not Applicable

All sequences(58) RefSeq(6) UniProt(5)

Polymorphisms

SNPs within 2kb(334 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009539	Strabismus
Protein Ontology	PR:000017255	Vang-like protein 1

References

(Earliest) J:70272 Kibar Z, et al., Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5
(Latest) J:215971 Gegg M, et al., Flattop regulates basal body docking and positioning in mono- and multiciliated cells. Elife. 2014;3
All references(61)