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Vangl1
Gene Detail
Symbol

Name
ID
Vangl1
vang-like 1 (van gogh, Drosophila)
MGI:2159344
Synonyms
KITENIN, Lpp2, mStbm, stbm
Feature Type
protein coding gene
Genetic Map
Chromosome 3
44.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:102153583-102204693 bp, - strand
From VEGA annotation of GRCm38

  51111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44540  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: VANGL1
Protein SuperFamily: Vang-like protein
Gene Tree: Vangl1

Human
homologs
VANGL1, VANGL planar cell polarity protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81839
neXtProt AC: NX_Q8TAA9

Human Synonyms: KITENIN, LPP2, STB2, STBM2

Human Chr (Location): 1p13.1; chr1:115641953-115698224 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VANGL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(86) : Gene trapped(81) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Vangl1 interacts with 249 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process multicellular organismal development
Component integral component of membrane, lateral plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (94)    Tissues (63)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 47
In situ reporter (knock in) 35
RT-PCR 3
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(38) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031053 (Evidence)
Ensembl Gene Model ENSMUSG00000027860 (Evidence)
Entrez Gene 229658 (Evidence)
UniGene 118004
DFCI TC1583921, TC1614089
DoTS DT.101218170, DT.528024, DT.91348763, DT.97397300
NIA Mouse Gene Index U118163
Consensus CDS Project CCDS17686.1, CCDS51024.1
International Mouse Phenotyping Consortium Status Vangl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031053 VEGA Gene Model | MGI Sequence Detail 51111 C57BL/6J ±  kb
transcript OTTMUST00000076931 VEGA | MGI Sequence Detail 6531 Not Applicable 
polypeptide OTTMUSP00000040562 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009539 Strabismus
Protein Ontology PR:000017255 Vang-like protein 1
References
(Earliest) J:70272 Kibar Z, et al., Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(62)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory