About   Help   FAQ
Nxf7 Gene Detail
Summary
  • Symbol
    Nxf7
  • Name
    nuclear RNA export factor 7
  • Synonyms
    nfx-a1, nxf-a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159343
    NCBI Gene: 170722
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:135579555-135598777 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 57.25 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159343
protein coding gene ChrX:135579555-135598777 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036085
protein coding gene ChrX:132918814-132940961 (-)
A/J MGP_AJ_G0036063
protein coding gene ChrX:132300703-132319845 (-)
AKR/J MGP_AKRJ_G0035989
protein coding gene ChrX:136536178-136565981 (-)
BALB/cJ MGP_BALBcJ_G0036053
protein coding gene ChrX:130715465-130735108 (-)
C3H/HeJ MGP_C3HHeJ_G0035763
protein coding gene ChrX:132890278-132910269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036575
protein coding gene ChrX:136707106-136728487 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033404
protein coding gene ChrX:124361052-124379706 (-)
CAST/EiJ MGP_CASTEiJ_G0035050
protein coding gene ChrX:113822122-113841526 (-)
CBA/J MGP_CBAJ_G0035737
protein coding gene ChrX:140910862-140932225 (-)
DBA/2J MGP_DBA2J_G0035893
protein coding gene ChrX:131639889-131664443 (-)
FVB/NJ MGP_FVBNJ_G0035830
protein coding gene ChrX:130839654-130859145 (-)
LP/J MGP_LPJ_G0035986
protein coding gene ChrX:133810625-133842168 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035864
protein coding gene ChrX:148292440-148312502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036611
protein coding gene ChrX:132254656-132275622 (-)
PWK/PhJ MGP_PWKPhJ_G0034741
protein coding gene ChrX:110735317-110755342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034573
protein coding gene ChrX:114454306-114474309 (-)
WSB/EiJ MGP_WSBEiJ_G0035183
protein coding gene ChrX:130604310-130624764 (-)



Homology
less
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170722 NCBI Gene Model | MGI Sequence Detail 19223 C57BL/6J ±  kb
transcript NM_130888 RefSeq | MGI Sequence Detail 2233 C57BL/6  
polypeptide NP_570958 RefSeq | MGI Sequence Detail 620 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR032710 NTF2-like domain superfamily
    IPR030217 Nuclear RNA export factor
    IPR030218 Nuclear RNA export factor 5
    IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
    IPR002075 Nuclear transport factor 2
    IPR018222 Nuclear transport factor 2, eukaryote
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR005637 TAP C-terminal (TAP-C) domain
    IPR009060 UBA-like superfamily
Molecular
Reagents
less
  • All nucleic 29
    cDNA 22
    Primer pair 7

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:71637 Jun L, et al., NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Curr Biol. 2001 Sep 18;11(18):1381-91
  • Latest
    J:224137 Callaerts-Vegh Z, et al., Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice. Front Behav Neurosci. 2015;9:179

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory