Ntng2 MGI Mouse Gene Detail - MGI:2159341

Symbol

Ntng2
Name

netrin G2
Synonyms

2610016D08Rik, Lmnt2

Feature Type

protein coding gene
IDs

MGI:2159341
NCBI Gene: 171171
Alliance

gene page

Sequence Map

Chr2:29084738-29138111 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 19.57 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

294 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159341	protein coding gene	Chr2:29084553-29143017 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025538	protein coding gene	Chr2:27314333-27377203 (-)
A/J	MGP_AJ_G0025515	protein coding gene	Chr2:26265751-26330064 (-)
AKR/J	MGP_AKRJ_G0025485	protein coding gene	Chr2:27143000-27202938 (-)
BALB/cJ	MGP_BALBcJ_G0025511	protein coding gene	Chr2:26393158-26453414 (-)
C3H/HeJ	MGP_C3HHeJ_G0025272	protein coding gene	Chr2:27062022-27125462 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025955	protein coding gene	Chr2:28213274-28276772 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023365	protein coding gene	Chr2:25070974-25128672 (-)
CAST/EiJ	MGP_CASTEiJ_G0024735	protein coding gene	Chr2:26963680-27025059 (-)
CBA/J	MGP_CBAJ_G0025250	protein coding gene	Chr2:29174746-29247952 (-)
DBA/2J	MGP_DBA2J_G0025383	protein coding gene	Chr2:26060634-26118780 (-)
FVB/NJ	MGP_FVBNJ_G0025345	protein coding gene	Chr2:25865164-25923624 (-)
LP/J	MGP_LPJ_G0025469	protein coding gene	Chr2:27248878-27319467 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025376	protein coding gene	Chr2:29159359-29220026 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026014	protein coding gene	Chr2:27051499-27114956 (-)
PWK/PhJ	MGP_PWKPhJ_G0024482	protein coding gene	Chr2:25875549-25936534 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024282	protein coding gene	Chr2:27154984-27218308 (-)
WSB/EiJ	MGP_WSBEiJ_G0024804	protein coding gene	Chr2:27182206-27250033 (-)

Human Ortholog

NTNG2, netrin G2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTNG2, netrin G2
Synonyms

bA479K20.1, LHLL9381, Lmnt2, NEDBASH, NetrinG2, NTNG1
Links

HGNC:14288

NCBI Gene ID: 84628

neXtProt AC: NX_Q96CW9

UniProt: Q96CW9
Chr Location

9q34.13; chr9:132161689-132244526 (+) GRCh38

MGI Vertebrate Homology

Ntng2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NTNG2
Gene Tree

Ntng2

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a null allele exhibit an absence of startle reflex and abnormal ABR amplitude.

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

89
cDNA Data

10
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ntng2

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All Sequences

54
RefSeq

6
UniProt

5
CCDS

CCDS15851.1, CCDS15852.1, CCDS84499.1

Ensembl

ENSMUSG00000035513 (Evidence)
NCBI Gene

171171

			Length	Strain/Species	Flank
genomic	171171	NCBI Gene Model \| MGI Sequence Detail	53374	C57BL/6J	± kb
transcript	NM_133501	RefSeq \| MGI Sequence Detail	1924	Not Specified
polypeptide	Q8R4F1	UniProt \| EBI \| MGI Sequence Detail	589	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011468 netrin-G2

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain

IPR036278 Sialidase superfamily

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 2

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MGI:1919701

Summaries

All 51

Developmental Gene Expression 17

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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