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Asic3 Gene Detail
Summary
  • Symbol
    Asic3
  • Name
    acid-sensing (proton-gated) ion channel 3
  • Synonyms
    Accn3, DRASIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159339
    NCBI Gene: 171209
  • Gene Overview
    MyGene.info: ASIC3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24413392-24417835 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 11.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159339
protein coding gene Chr5:24410289-24417835 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029341
protein coding gene Chr5:22139113-22143555 (+)
A/J MGP_AJ_G0029307
protein coding gene Chr5:21386144-21390587 (+)
AKR/J MGP_AKRJ_G0029258
protein coding gene Chr5:22246450-22250893 (+)
BALB/cJ MGP_BALBcJ_G0029318
protein coding gene Chr5:21899288-21903731 (+)
C3H/HeJ MGP_C3HHeJ_G0029038
protein coding gene Chr5:22359591-22364034 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029771
protein coding gene Chr5:23634402-23638845 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027009
protein coding gene Chr5:19328564-19332991 (+)
CAST/EiJ MGP_CASTEiJ_G0028450
protein coding gene Chr5:21533481-21537921 (+)
CBA/J MGP_CBAJ_G0029005
protein coding gene Chr5:24019377-24023820 (+)
DBA/2J MGP_DBA2J_G0029156
protein coding gene Chr5:21679349-21683787 (+)
FVB/NJ MGP_FVBNJ_G0029114
protein coding gene Chr5:21047825-21052282 (+)
LP/J MGP_LPJ_G0029240
protein coding gene Chr5:22539011-22543453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029143
protein coding gene Chr5:25143549-25147992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029805
protein coding gene Chr5:21888674-21893115 (+)
PWK/PhJ MGP_PWKPhJ_G0028174
protein coding gene Chr5:20757069-20761682 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028005
protein coding gene Chr5:21245531-21250027 (+)
WSB/EiJ MGP_WSBEiJ_G0028530
protein coding gene Chr5:21954163-21958604 (+)



Homology
more
  • Human Ortholog
    ASIC3, acid sensing ion channel subunit 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ASIC3, acid sensing ion channel subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACCN3, DRASIC, SLNAC1, TNaC1
  • Links
    NCBI Gene ID: 9311
    neXtProt AC: NX_Q9UHC3
    UniProt: Q9UHC3

  • Chr Location
    7q36.1; chr7:151048292-151052756 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038276 Ensembl Gene Model | MGI Sequence Detail 4444 C57BL/6J ±  kb
    transcript ENSMUST00000196296 Ensembl | MGI Sequence Detail 1593 Not Applicable  
    polypeptide ENSMUSP00000143083 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141243
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:259761 Detweiler ND, et al., Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. PLoS One. 2018;13(2):e0192724

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory