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Asic3
Gene Detail
 Symbol
Name
ID
Asic3
acid-sensing (proton-gated) ion channel 3
MGI:2159339
Synonyms Accn3, DRASIC
Feature Type protein coding gene
Genetic Map
Chromosome 5
11.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:24413451-24417834 bp, + strand
From NCBI annotation of GRCm38

  4384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Asic3

Human
homologs
Human Homolog ASIC3, acid-sensing (proton-gated) ion channel 3
NCBI Gene ID 9311
neXtProt AC  NX_Q9UHC3
Human Synonyms  ACCN3, DRASIC, SLNAC1, TNaC1
Human Chr (Location)  7q35; chr7:151048292-151052756 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors.
 
Interactions
Asic3 interacts with 14 markers (Mir22, Mir27b, Mir129-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cation transport, detection of chemical stimulus involved in sensory perception, ...
Component cytoplasm, integral component of membrane, ...
Function cation channel activity, enterobactin transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (7)    Images (17)
Theiler Stages: 23
Assay TypeResults
RNA in situ 46
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000038276 (Evidence)
Entrez Gene171209 (Evidence)
UniGene299636
DFCITC1586261, TC1613558, TC1694974
DoTSDT.101254894, DT.55118000, DT.97399474
NIA Mouse Gene IndexU005361
Consensus CDS ProjectCCDS51433.1
International Mouse Knockout Project StatusAsic3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 171209 NCBI Gene Model | MGI Sequence Detail 4384 C57BL/6J ±  kb
transcript NM_183000 RefSeq | MGI Sequence Detail 1978 Not Specified 
polypeptide Q6X1Y6 UniProt | EBI | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(7) UniProt(1)
Polymorphisms SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004724 Epithelial sodium channel
InterPro IPR001873 Na+ channel, amiloride-sensitive
InterPro IPR020903 Na+ channel, amiloride-sensitive, conserved site
Protein Ontology PR:000003616 acid-sensing ion channel 3
Graphical View of Protein Domain Structure
References (Earliest) J:73505 Price MP, et al., The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice. Neuron. 2001 Dec 20;32(6):1071-83
(Latest) J:196286 Wang X, et al., Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. J Neurosci. 2013 Mar 6;33(10):4265-79
All references(60)
Other
accession IDs
MGI:2141243

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory