Tiparp MGI Mouse Gene Detail - MGI:2159210 - TCDD-inducible poly(ADP-ribose) polymerase

Symbol

Tiparp
Name

TCDD-inducible poly(ADP-ribose) polymerase
Synonyms

DDF1, PARP-7, PARP7

Feature Type

protein coding gene
IDs

MGI:2159210
NCBI Gene: 99929
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:65435868-65462939 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.20 cM
Mapping Data

1 experiment

SNPs within 2kb

470 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159210	protein coding gene	Chr3:65435831-65462939 (+)
129S1/SvImJ	ENSMUSG00200001298	protein coding gene	Chr3:62183159-62210366 (+)
A/J	ENSMUSG00195026087	protein coding gene	Chr3:62300177-62327286 (+)
AKR/J	ENSMUSG00220024430	protein coding gene	Chr3:62308247-62335302 (+)
BALB/cJ	ENSMUSG00180008247	protein coding gene	Chr3:62326664-62353718 (+)
C3H/HeJ	ENSMUSG00175003382	protein coding gene	Chr3:62188516-62215624 (+)
C57BL/6NJ	ENSMUSG00215006036	protein coding gene	Chr3:62662376-62689484 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025044	protein coding gene	Chr3:59160750-59187922 (+)
CAST/EiJ	ENSTCUG00005002324	protein coding gene	Chr3:61898727-61925934 (+)
CBA/J	ENSMUSG00210002119	protein coding gene	Chr3:62274121-62301230 (+)
DBA/2J	ENSMUSG00185014537	protein coding gene	Chr3:62442880-62469989 (+)
FVB/NJ	ENSMUSG00205003312	protein coding gene	Chr3:61434241-61461296 (+)
JF1/MsJ	ENSUMUG00000000866	protein coding gene	Chr3:62100283-62127506 (+)
LP/J	ENSMUSG00230001735	protein coding gene	Chr3:64467736-64494944 (+)
NOD/ShiLtJ	ENSMUSG00190003082	protein coding gene	Chr3:62751455-62778563 (+)
NZO/HlLtJ	ENSMUSG00225001467	protein coding gene	Chr3:67190925-67217978 (+)
PWK/PhJ	ENSLUMG00010014955	protein coding gene	Chr3:62147658-62174869 (+)
SPRET/EiJ	ENSMSPG00010007722	protein coding gene	Chr3:62637790-62665052 (+)
WSB/EiJ	ENSIUOG00005015756	protein coding gene	Chr3:62692104-62719320 (+)

Human Ortholog

TIPARP, TCDD inducible poly(ADP-ribose) polymerase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIPARP, TCDD inducible poly(ADP-ribose) polymerase
Synonyms

ARTD14, PARP7, pART14
Links

HGNC:23696

NCBI Gene ID: 25976

UniProt: Q7Z3E1
Chr Location

3q25.31; chr3:156673235-156706770 (+) GRCh38

MGI Vertebrate Homology

Tiparp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TIPARP
Gene Tree

Tiparp

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References

1 with disease annotations

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Phenotype Summary

53 phenotypes from 2 alleles in 4 genetic backgrounds
9 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

6
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Tiparp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects, kidney defects and embryonic hemorrhaging.

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All GO Annotations

43
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

614
Tissues

12
cDNA Data

90
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tiparp

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS17388.1

Ensembl

ENSMUSG00000034640 (Evidence)
NCBI Gene

99929

			Length	Strain/Species	Flank
genomic	99929	NCBI Gene Model \| MGI Sequence Detail	27072	C57BL/6J	± kb
transcript	NM_178892	RefSeq \| MGI Sequence Detail	4154	C57BL/6
polypeptide	Q8C1B2	UniProt \| EBI \| MGI Sequence Detail	657	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016360 protein mono-ADP-ribosyltransferase TIPARP

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR051712 Mono-ADP-ribosyltransferase and antiviral protein

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR004170 WWE domain

IPR037197 WWE domain superfamily

IPR000571 Zinc finger, CCCH-type

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All nucleic 93

cDNA 90

Primer pair 2

Other 1

Microarray probesets 5

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MGI:2140010

Summaries

All 66

Developmental Gene Expression 6

Diseases 1

Gene Ontology 10

Phenotypes 30
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:387682 Jeltema D, et al., PARP7 protects the lung epithelial barrier from diverse environmental threats. Proc Natl Acad Sci U S A. 2026 Mar 10;123(10):e2525274123

TSS for Tiparp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29403	Chr3:65435222-65435265 (+)	-624 bp
Tssr29404	Chr3:65435422-65435442 (+)	-436 bp
Tssr29405	Chr3:65435825-65435852 (+)	-29 bp
Tssr29406	Chr3:65435855-65435875 (+)	-3 bp
Tssr29407	Chr3:65435878-65435892 (+)	17 bp
Tssr29408	Chr3:65438667-65438681 (+)	2,806 bp
Tssr29409	Chr3:65439086-65439116 (+)	3,233 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24