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Tiparp
Gene Detail
Symbol

Name
ID
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
MGI:2159210
Synonyms
DDF1, PARP7, PARP-7
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:65528410-65555518 bp, + strand
From VEGA annotation of GRCm38

  27109 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TIPARP
Gene Tree: Tiparp

Human
homologs
TIPARP, TCDD-inducible poly(ADP-ribose) polymerase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25976
neXtProt AC: NX_Q7Z3E1

Human Synonyms: ARTD14, PARP7, pART14

Human Chr (Location): 3q25.31; chr3:156674416-156706770 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects, kidney defects and embryonic hemorrhaging.
 
Interactions
Tiparp interacts with 290 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process androgen metabolic process, cellular response to organic cyclic compound, ...
Component nucleus
Function enhancer binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 1
cDNA source data(89)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tiparp    NEW 
Molecular
reagents
All nucleic(90) cDNA(89) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022169 (Evidence)
Ensembl Gene Model ENSMUSG00000034640 (Evidence)
Entrez Gene 99929 (Evidence)
UniGene 246398
DFCI TC1572813
DoTS DT.101205570, DT.94202051, DT.87069704
NIA Mouse Gene Index U003299
EC 2.4.2.30
Consensus CDS Project CCDS17388.1
International Mouse Phenotyping Consortium Status Tiparp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022169 VEGA Gene Model | MGI Sequence Detail 27109 C57BL/6J ±  kb
transcript OTTMUST00000052639 VEGA | MGI Sequence Detail 4191 Not Applicable 
polypeptide OTTMUSP00000024986 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
InterPro IPR004170 WWE domain
InterPro IPR000571 Zinc finger, CCCH-type
Protein Ontology PR:000016360 TCDD-inducible poly [ADP-ribose] polymerase
References
(Earliest) J:73109 Ma Q, et al., TCDD-Inducible Poly(ADP-ribose) Polymerase: A Novel Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Biochem Biophys Res Commun. 2001 Nov 30;289(2):499-506
(Latest) J:200218 MacPherson L, et al., 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013 Feb 1;41(3):1604-21
All references(36)
Other
accession IDs
MGI:2140010

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory