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Tiparp Gene Detail
Summary
  • Symbol
    Tiparp
  • Name
    TCDD-inducible poly(ADP-ribose) polymerase
  • Synonyms
    DDF1, PARP7, PARP-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159210
    NCBI Gene: 99929
  • Gene Overview
    MyGene.info: TIPARP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:65528410-65555518 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27109 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TIPARP, TCDD inducible poly(ADP-ribose) polymerase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TIPARP, TCDD inducible poly(ADP-ribose) polymerase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARTD14, PARP7, pART14
  • Links
    NCBI Gene ID: 25976
    neXtProt AC: NX_Q7Z3E1
    UniProt: Q7Z3E1

  • Chr Location
    3q25.31; chr3:156674416-156706770 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9167
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TIPARP
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit postnatal lethality, skeletal and craniofacial defects, kidney defects and embryonic hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022169 VEGA Gene Model | MGI Sequence Detail 27109 C57BL/6J ±  kb
    transcript OTTMUST00000052639 VEGA | MGI Sequence Detail 4191 Not Applicable  
    polypeptide OTTMUSP00000024986 VEGA | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      156 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140010
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:250062 Li A, et al., Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016 Mar 16;14(None):19

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory