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Sumo2 Gene Detail
Summary
  • Symbol
    Sumo2
  • Name
    small ubiquitin-like modifier 2
  • Synonyms
    Smt3b, Smt3h2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158813
    NCBI Gene: 170930
  • Gene Overview
    MyGene.info: SUMO2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:115523102-115536276 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13175 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.84 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SUMO2, small ubiquitin-like modifier 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUMO2, small ubiquitin-like modifier 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSMT3, Smt3A, SMT3B, SMT3H2, SUMO3
  • Links
    NCBI Gene ID: 6613
    neXtProt AC: NX_P61956
    UniProt: P61956

  • Chr Location
    17q25.1; chr17:75167730-75183003 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display severe embryonic growth retardation and die at approximately embryonic day E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003474 VEGA Gene Model | MGI Sequence Detail 13175 C57BL/6J ±  kb
    transcript OTTMUST00000007409 VEGA | MGI Sequence Detail 1051 Not Applicable  
    polypeptide OTTMUSP00000003569 VEGA | MGI Sequence Detail 95 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      81 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 15
      Primer pair 4
      Other 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:52460 Chen A, et al., Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes. Biochem Mol Biol Int. 1998 Dec;46(6):1161-74
    • Latest
      J:257912 Feitosa WB, et al., Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis. Dev Biol. 2018 Feb 15;434(2):278-291

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory