About   Help   FAQ
Senp3 Gene Detail
Summary
  • Symbol
    Senp3
  • Name
    SUMO/sentrin specific peptidase 3
  • Synonyms
    Smt3ip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158736
    NCBI Gene: 80886
  • Gene Overview
    MyGene.info: SENP3
Location & Maps
more
  • Sequence Map
    Chr11:69673115-69682084 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8970 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SENP3, SUMO1/sentrin/SMT3 specific peptidase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SENP3, SUMO1/sentrin/SMT3 specific peptidase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SMT3IP1, SSP3, Ulp1
  • Links
    NCBI Gene ID: 26168
    neXtProt AC: NX_Q9H4L4

  • Chr Location
    17p13; chr17:7561992-7571969 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    6
  • Genomic Mutations
    2 involving Senp3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006011 VEGA Gene Model | MGI Sequence Detail 8970 C57BL/6J ±  kb
transcript OTTMUST00000013467 VEGA | MGI Sequence Detail 2313 Not Applicable  
polypeptide OTTMUSP00000006235 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    71 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR003653 Ulp1 protease family, C-terminal catalytic domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145550
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:73476 Nishida T, et al., A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur J Biochem. 2000 Nov;267(21):6423-7
  • Latest
    J:198373 Guo C, et al., SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. EMBO J. 2013 May 29;32(11):1514-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory