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Senp3 Gene Detail
Summary
  • Symbol
    Senp3
  • Name
    SUMO/sentrin specific peptidase 3
  • Synonyms
    Smt3ip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158736
    NCBI Gene: 80886
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69563941-69572910 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158736
 protein coding gene Chr11:69563936-69572910 (-)
129S1/SvImJ ENSMUSG00200042694
 protein coding gene Chr11:66509992-66518961 (-)
A/J ENSMUSG00195035415
 protein coding gene Chr11:66536743-66545925 (-)
AKR/J ENSMUSG00220041375
 protein coding gene Chr11:66645175-66654148 (-)
BALB/cJ ENSMUSG00180043411
 protein coding gene Chr11:66606644-66615618 (-)
C3H/HeJ ENSMUSG00175054350
 protein coding gene Chr11:66556879-66565847 (-)
C57BL/6NJ ENSMUSG00215052761
 protein coding gene Chr11:66333272-66342245 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016583
 protein coding gene Chr11:64408658-64418024 (-)
CAST/EiJ ENSTCUG00005048066
 protein coding gene Chr11:66096873-66105998 (-)
CBA/J ENSMUSG00210054239
 protein coding gene Chr11:66410964-66419934 (-)
DBA/2J ENSMUSG00185055353
 protein coding gene Chr11:66609973-66618971 (-)
FVB/NJ ENSMUSG00205053534
 protein coding gene Chr11:66502267-66511238 (-)
JF1/MsJ ENSUMUG00000056973
 protein coding gene Chr11:67008326-67017324 (-)
LP/J ENSMUSG00230052153
 protein coding gene Chr11:67720351-67729319 (-)
NOD/ShiLtJ ENSMUSG00190053217
 protein coding gene Chr11:66639868-66648837 (-)
NZO/HlLtJ ENSMUSG00225047324
 protein coding gene Chr11:69902203-69911383 (-)
PWK/PhJ ENSLUMG00010053266
 protein coding gene Chr11:66526401-66535375 (-)
SPRET/EiJ ENSMSPG00010041237
 protein coding gene Chr11:67253974-67262908 (-)
WSB/EiJ ENSIUOG00005043714
 protein coding gene Chr11:66539551-66548533 (-)



Homology
more
  • Human Ortholog
    SENP3, SUMO specific peptidase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SENP3, SUMO specific peptidase 3
  • Synonyms
    SMT3IP1, SSP3, Ulp1
  • Links
    NCBI Gene ID: 26168
    UniProt: Q9H4L4

  • Chr Location
    17p13.1; chr17:7561919-7571969 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    13
  • cDNA Data
    6
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005204 Ensembl Gene Model | MGI Sequence Detail 8970 C57BL/6J ±  kb
    transcript ENSMUST00000005336 Ensembl | MGI Sequence Detail 2313 Not Applicable  
    polypeptide ENSMUSP00000005336 Ensembl | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      3.4.22.-
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR045577 Sentrin-specific protease 3/5, conserved domain
      IPR003653 Ulp1 protease family, C-terminal catalytic domain
    • GlyGen
      Q9EP97 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145550
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391233 Chen L, et al., SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De-SUMOylation of CTH. Adv Sci (Weinh). 2025 Apr;12(16):e2414500
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory