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Senp3 Gene Detail
Summary
  • Symbol
    Senp3
  • Name
    SUMO/sentrin specific peptidase 3
  • Synonyms
    Smt3ip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158736
    NCBI Gene: 80886
  • Gene Overview
    MyGene.info: SENP3
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69673115-69682084 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158736
protein coding gene Chr11:69673110-69682084 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018547
protein coding gene Chr11:70132129-70141096 (-)
A/J MGP_AJ_G0018515
protein coding gene Chr11:67489147-67499032 (-)
AKR/J MGP_AKRJ_G0018484
protein coding gene Chr11:69497908-69508777 (-)
BALB/cJ MGP_BALBcJ_G0018487
protein coding gene Chr11:67798854-67808459 (-)
C3H/HeJ MGP_C3HHeJ_G0018300
protein coding gene Chr11:69530282-69540183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018938
protein coding gene Chr11:72252975-72262150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016583
protein coding gene Chr11:64408658-64418024 (-)
CAST/EiJ MGP_CASTEiJ_G0017855
protein coding gene Chr11:69769868-69781865 (-)
CBA/J MGP_CBAJ_G0018273
protein coding gene Chr11:75489551-75498508 (-)
DBA/2J MGP_DBA2J_G0018382
protein coding gene Chr11:67072052-67081502 (-)
FVB/NJ MGP_FVBNJ_G0018372
protein coding gene Chr11:66714483-66724806 (-)
LP/J MGP_LPJ_G0018452
protein coding gene Chr11:70698678-70709659 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018395
protein coding gene Chr11:76080072-76089052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018980
protein coding gene Chr11:69761402-69770402 (-)
PWK/PhJ MGP_PWKPhJ_G0017629
protein coding gene Chr11:67722182-67731365 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017419
protein coding gene Chr11:69581415-69590349 (-)
WSB/EiJ MGP_WSBEiJ_G0017909
protein coding gene Chr11:69433297-69442704 (-)



Homology
more
  • Human Ortholog
    SENP3, SUMO specific peptidase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SENP3, SUMO specific peptidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMT3IP1, SSP3, Ulp1
  • Links
    NCBI Gene ID: 26168
    neXtProt AC: NX_Q9H4L4
    UniProt: Q9H4L4

  • Chr Location
    17p13.1; chr17:7561992-7571969 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005204 Ensembl Gene Model | MGI Sequence Detail 8970 C57BL/6J ±  kb
transcript ENSMUST00000005336 Ensembl | MGI Sequence Detail 2313 Not Applicable  
polypeptide ENSMUSP00000005336 Ensembl | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR037945 Sentrin-specific protease 3
    IPR003653 Ulp1 protease family, C-terminal catalytic domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
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MGI:2145550
References
more
  • Summaries
    All 43
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:198373 Guo C, et al., SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. EMBO J. 2013 May 29;32(11):1514-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory