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Inpp5j Gene Detail
Summary
  • Symbol
    Inpp5j
  • Name
    inositol polyphosphate 5-phosphatase J
  • Synonyms
    Pib5pa, Pipp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158663
    NCBI Gene: 170835
  • Gene Overview
    MyGene.info: INPP5J
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3494375-3504821 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158663
protein coding gene Chr11:3494272-3505560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017959
protein coding gene Chr11:366875-378015 (-)
A/J MGP_AJ_G0017932
protein coding gene Chr11:412009-422452 (-)
AKR/J MGP_AKRJ_G0017896
protein coding gene Chr11:429910-440893 (-)
BALB/cJ MGP_BALBcJ_G0017900
protein coding gene Chr11:383780-394739 (-)
C3H/HeJ MGP_C3HHeJ_G0017713
protein coding gene Chr11:364801-375815 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018353
protein coding gene Chr11:437886-448895 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016012
protein coding gene Chr11:321141-331612 (-)
CAST/EiJ MGP_CASTEiJ_G0017275
protein coding gene Chr11:319185-330325 (-)
CBA/J MGP_CBAJ_G0017688
protein coding gene Chr11:602672-616665 (-)
DBA/2J MGP_DBA2J_G0017799
protein coding gene Chr11:330616-341605 (-)
FVB/NJ MGP_FVBNJ_G0017790
protein coding gene Chr11:361156-372300 (-)
LP/J MGP_LPJ_G0017869
protein coding gene Chr11:464393-475205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017816
protein coding gene Chr11:349751-360745 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018392
protein coding gene Chr11:440440-453266 (-)
PWK/PhJ MGP_PWKPhJ_G0017055
protein coding gene Chr11:304979-316104 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016851
protein coding gene Chr11:394637-405425 (-)
WSB/EiJ MGP_WSBEiJ_G0017329
protein coding gene Chr11:317776-328895 (-)



Homology
more
  • Human Ortholog
    INPP5J, inositol polyphosphate-5-phosphatase J
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INPP5J, inositol polyphosphate-5-phosphatase J
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INPP5, PIB5PA, PIPP
  • Links
    NCBI Gene ID: 27124
    neXtProt AC: NX_Q15735
    UniProt: Q15735

  • Chr Location
    22q12.2; chr22:31107736-31134697 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    6 phenotypes from multigenic genotypes
    2 phenotype references
Mice homozygous for a null allele are viable, fertile, and show normal mammary gland development and no spontaneous mammary tumors. However, in an oncogene-driven breast cancer mouse model, mice show increased mammary hyperplasia and tumor growth paradoxically associated with reduced lung metastases.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034570 Ensembl Gene Model | MGI Sequence Detail 10447 C57BL/6J ±  kb
transcript ENSMUST00000044507 Ensembl | MGI Sequence Detail 3370 Not Applicable  
polypeptide ENSMUSP00000046625 Ensembl | MGI Sequence Detail 1003 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 2
  • Earliest
    J:82579 Gurung R, et al., Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem. 2003 Mar 28;278(13):11376-85
  • Latest
    J:224914 Ooms LM, et al., The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell. 2015 Aug 10;28(2):155-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory