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Idh3b
Gene Detail
Symbol

Name
ID
Idh3b
isocitrate dehydrogenase 3 (NAD+) beta
MGI:2158650
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.20 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:130279309-130284547 bp, - strand
From VEGA annotation of GRCm38

  5239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IDH3B
Protein SuperFamily: 3-isopropylmalate dehydrogenase
Gene Tree: Idh3b

Human
homologs
IDH3B, isocitrate dehydrogenase 3 (NAD+) beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3420
neXtProt AC: NX_O43837

Human Synonyms: H-IDHB, RP46

Human Chr (Location): 20p13; chr20:2658394-2664219 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IDH3B

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Idh3b interacts with 64 markers (Mir29b-2, Mir34b, Mir127, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process 2-oxoglutarate metabolic process, isocitrate metabolic process, ...
Component mitochondrion, nucleus
Function isocitrate dehydrogenase (NAD+) activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (118)    Tissues (97)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase idh3b    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000015521 (Evidence)
Ensembl Gene Model ENSMUSG00000027406 (Evidence)
Entrez Gene 170718 (Evidence)
DFCI TC1774341, TC1667790, TC1606847, TC1572606
DoTS DT.91329254, DT.55138816, DT.91441076, DT.94145181, DT.94241581, DT.94186183, DT.99872247
NIA Mouse Gene Index U023353
EC 1.1.1.41
Consensus CDS Project CCDS16738.1
International Mouse Phenotyping Consortium Status Idh3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015521 VEGA Gene Model | MGI Sequence Detail 5239 C57BL/6J ±  kb
transcript OTTMUST00000036851 VEGA | MGI Sequence Detail 1616 Not Applicable 
polypeptide OTTMUSP00000016536 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001804 Isocitrate and isopropylmalate dehydrogenases family
InterPro IPR004434 Isocitrate dehydrogenase NAD-dependent
InterPro IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro IPR024084 Isopropylmalate dehydrogenase-like domain
Protein Ontology PR:000008890 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)
Other
accession IDs
MGI:2139470

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory