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Cep63 Gene Detail
Summary
  • Symbol
    Cep63
  • Name
    centrosomal protein 63
  • Synonyms
    CD20R, D9Mgc41, D9Mgc48e, ET2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158560
    NCBI Gene: 28135
  • Gene Overview
    MyGene.info: CEP63
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102586578-102626546 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158560
protein coding gene Chr9:102584588-102626546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035187
protein coding gene Chr9:104151059-104197816 (-)
A/J MGP_AJ_G0035167
protein coding gene Chr9:100412931-100456162 (-)
AKR/J MGP_AKRJ_G0035099
protein coding gene Chr9:102884039-102927796 (-)
BALB/cJ MGP_BALBcJ_G0035160
protein coding gene Chr9:100124923-100167952 (-)
C3H/HeJ MGP_C3HHeJ_G0034870
protein coding gene Chr9:103295679-103340206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035680
protein coding gene Chr9:107058617-107110217 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032579
protein coding gene Chr9:98007558-98048191 (-)
CAST/EiJ MGP_CASTEiJ_G0034182
protein coding gene Chr9:103106744-103155995 (-)
CBA/J MGP_CBAJ_G0034839
protein coding gene Chr9:110788377-110843072 (-)
DBA/2J MGP_DBA2J_G0035000
protein coding gene Chr9:99912030-99954663 (-)
FVB/NJ MGP_FVBNJ_G0034948
protein coding gene Chr9:98707849-98751178 (-)
LP/J MGP_LPJ_G0035076
protein coding gene Chr9:104353131-104399985 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034987
protein coding gene Chr9:112625543-112669961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035702
protein coding gene Chr9:103138327-103185209 (-)
PWK/PhJ MGP_PWKPhJ_G0033889
protein coding gene Chr9:100148909-100191097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033724
protein coding gene Chr9:103170067-103222166 (-)
WSB/EiJ MGP_WSBEiJ_G0034302
protein coding gene Chr9:103017414-103059763 (-)



Homology
more
  • Human Ortholog
    CEP63, centrosomal protein 63
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP63, centrosomal protein 63
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCKL6
  • Links
    NCBI Gene ID: 80254
    neXtProt AC: NX_Q96MT8
    UniProt: Q96MT8

  • Chr Location
    3q22.2; chr3:134485733-134629607 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11861
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CEP63
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cep63 mouse models; 1 with human CEP63 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth defects, microcephaly, thin cerebral cortex, mitotic defects and cell death in neural progenitors, decreased oocyte number, small testis, and severely impaired spermatogenesis and meiotic recombination leading to male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28135 NCBI Gene Model | MGI Sequence Detail 39969 C57BL/6J ±  kb
    transcript NM_001081122 RefSeq | MGI Sequence Detail 2696 C57BL/6  
    polypeptide Q3UPP8 UniProt | EBI | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 6
      cDNA 66
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1330278, MGI:1330303, MGI:2143291
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:52081 Blanco G, et al., A STS content physical and transcription map across the ky, kyphoscoliosis, nonrecombinant region. Genomics. 1998 Dec 15;54(3):415-23
    • Latest
      J:250399 Jayaraman D, et al., Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23;92(4):813-828

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory