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Cep63 Gene Detail
Summary
  • Symbol
    Cep63
  • Name
    centrosomal protein 63
  • Synonyms
    CD20R, D9Mgc41, D9Mgc48e, ET2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158560
    NCBI Gene: 28135
  • Gene Overview
    MyGene.info: CEP63
Location & Maps
more
  • Sequence Map
    Chr9:102584598-102626534 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41937 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CEP63, centrosomal protein 63
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP63, centrosomal protein 63
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCKL6
  • Links
    NCBI Gene ID: 80254
    neXtProt AC: NX_Q96MT8

  • Chr Location
    3q22.2; chr3:134485733-134575013 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11861
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CEP63
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CEP63 associations

Human Disease Mouse Models
       Seckel Syndrome 6; SCKL6   OMIM: 614728
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034608 VEGA Gene Model | MGI Sequence Detail 41937 C57BL/6J ±  kb
transcript OTTMUST00000087812 VEGA | MGI Sequence Detail 2696 Not Applicable  
polypeptide OTTMUSP00000047821 VEGA | MGI Sequence Detail 758 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    352 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005353 centrosomal protein of 63 kDa
  • InterPro Domains
    IPR031470 Centrosomal protein Cep63/Deup1, N-terminal
Molecular
Reagents
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  • All nucleic 72
    Genomic 6
    cDNA 64
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1330278, MGI:1330303, MGI:2143291
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:52081 Blanco G, et al., A STS content physical and transcription map across the ky, kyphoscoliosis, nonrecombinant region. Genomics. 1998 Dec 15;54(3):415-23
  • Latest
    J:224364 Marjanovic M, et al., CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nat Commun. 2015;6:7676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory