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Mbd3l2 Gene Detail
Summary
  • Symbol
    Mbd3l2
  • Name
    methyl-CpG binding domain protein 3-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158460
    NCBI Gene: 234988
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:18430654-18446316 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
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  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158460
protein coding gene Chr9:18430615-18446316 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034375
protein coding gene Chr9:15472713-15475569 (+)
A/J MGP_AJ_G0034354
protein coding gene Chr9:15341449-15344305 (+)
AKR/J MGP_AKRJ_G0034282
protein coding gene Chr9:15483458-15486314 (+)
BALB/cJ MGP_BALBcJ_G0034346
protein coding gene Chr9:15168365-15171207 (+)
C3H/HeJ MGP_C3HHeJ_G0034059
protein coding gene Chr9:15772874-15775730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034869
protein coding gene Chr9:16055144-16058000 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031806
protein coding gene Chr9:14423695-14428582 (+)
CAST/EiJ MGP_CASTEiJ_G0033385
protein coding gene Chr9:15610217-15613063 (+)
CBA/J MGP_CBAJ_G0034032
protein coding gene Chr9:16732546-16735402 (+)
DBA/2J MGP_DBA2J_G0034189
protein coding gene Chr9:15194949-15197805 (+)
FVB/NJ MGP_FVBNJ_G0034133
protein coding gene Chr9:14753057-14755913 (+)
LP/J MGP_LPJ_G0034275
protein coding gene Chr9:15691103-15693959 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034178
protein coding gene Chr9:17882297-17885153 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034888
protein coding gene Chr9:15476930-15479786 (+)
PWK/PhJ MGP_PWKPhJ_G0033091
protein coding gene Chr9:15251120-15253975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032926
protein coding gene Chr9:15516213-15519084 (+)
WSB/EiJ MGP_WSBEiJ_G0033502
protein coding gene Chr9:15271753-15274609 (+)



Homology
more
  • Human Ortholog
    MBD3L2, methyl-CpG binding domain protein 3 like 2
  • Vertebrate Orthologs
    19
  • Human Ortholog
    MBD3L2, methyl-CpG binding domain protein 3 like 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 125997
    neXtProt AC: NX_Q8NHZ7
    UniProt: Q8NHZ7

  • Chr Location
    19p13.2; chr19:7049340-7051735 (+)  GRCh38.p7

  • Human Ortholog
    MBD3L2B, methyl-CpG binding domain protein 3 like 2B
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 729458
    UniProt: A0A1B0GVZ6

  • Chr Location
    19p13.2; chr19:7019161-7020224 (-)  GRCh38.p7

  • Human Ortholog
    MBD3L3, methyl-CpG binding domain protein 3 like 3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 653657
    neXtProt AC: NX_A6NE82
    UniProt: A6NE82

  • Chr Location
    19p13.2; chr19:7056205-7058634 (-)  GRCh38.p7

  • Human Ortholog
    MBD3L4, methyl-CpG binding domain protein 3 like 4
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 653656
    neXtProt AC: NX_A6NDZ8
    UniProt: A6NDZ8

  • Chr Location
    19p13.2; chr19:7037744-7040173 (-)  GRCh38.p7

  • Human Ortholog
    MBD3L5, methyl-CpG binding domain protein 3 like 5
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 284428
    neXtProt AC: NX_A6NJ08
    UniProt: A6NJ08

  • Chr Location
    19p13.2; chr19:7030583-7033011 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    2 phenotype references
Homozygous null mice are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047508 Ensembl Gene Model | MGI Sequence Detail 15663 C57BL/6J ±  kb
transcript ENSMUST00000051008 Ensembl | MGI Sequence Detail 2075 Not Applicable  
polypeptide ENSMUSP00000054515 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region
    IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 5
References
more
  • Summaries
    All 21
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:80802 Jiang CL, et al., MBD3L1 and MBD3L2, Two New Proteins Homologous to the Methyl-CpG-Binding Proteins MBD2 and MBD3: Characterization of MBD3L1 as a Testis-Specific Transcriptional Repressor. Genomics. 2002 Dec;80(6):621-9
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory