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Med16 Gene Detail
Summary
  • Symbol
    Med16
  • Name
    mediator complex subunit 16
  • Synonyms
    95kDa, Thrap5, Trap95
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158394
    NCBI Gene: 216154
  • Gene Overview
    MyGene.info: MED16
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:79894708-79908923 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14216 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MED16, mediator complex subunit 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED16, mediator complex subunit 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRIP92, THRAP5, TRAP95
  • Links
    NCBI Gene ID: 10025
    neXtProt AC: NX_Q9Y2X0
    UniProt: Q9Y2X0

  • Chr Location
    19p13.3; chr19:867961-893228 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 64602
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED16
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035229 VEGA Gene Model | MGI Sequence Detail 14216 C57BL/6J ±  kb
    transcript OTTMUST00000089795 VEGA | MGI Sequence Detail 2950 Not Applicable  
    polypeptide OTTMUSP00000049104 VEGA | MGI Sequence Detail 865 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      45 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR021665 Mediator complex, subunit Med16
      IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
      IPR001680 WD40 repeat
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
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    • All nucleic 58
      Genomic 1
      cDNA 57

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:235993 Sekine H, et al., The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Mol Cell Biol. 2015 Nov 16;36(3):407-20

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory