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Rln3
Gene Detail
Symbol

Name
ID
Rln3
relaxin 3
MGI:2158015
Synonyms
M3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
40.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:84042929-84045000 bp, - strand
From VEGA annotation of GRCm38

  2072 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: RLN3
Protein SuperFamily: relaxin-3/insulin-like peptide 5
Gene Tree: Rln3

Human
homologs
RLN3, relaxin 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 117579
neXtProt AC: NX_Q8WXF3

Human Synonyms: H3, insl7, RXN3, ZINS4

Human Chr (Location): 19p13.2; chr19:14028205-14030971 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal body weight regulation, actvity levels, social investigation and behavioral despair.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process positive regulation of cAMP biosynthetic process
Component extracellular region
Function G-protein coupled receptor binding, hormone activity
External Resources: FuncBase
Expression
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rln3 ; ZFIN rln3a, rln3b    NEW 
Molecular
reagents
All nucleic(3) cDNA(2) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000044340 (Evidence)
Ensembl Gene Model ENSMUSG00000045232 (Evidence)
Entrez Gene 212108 (Evidence)
UniGene 261583
DFCI TC1651902
DoTS DT.101354193
NIA Mouse Gene Index U057340
Consensus CDS Project CCDS22466.1
International Mouse Phenotyping Consortium Status Rln3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044340 VEGA Gene Model | MGI Sequence Detail 2072 C57BL/6J ±  kb
transcript OTTMUST00000116688 VEGA | MGI Sequence Detail 634 Not Applicable 
polypeptide OTTMUSP00000065053 VEGA | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
Protein Ontology PR:000014035 relaxin-3
References
(Earliest) J:73691 Bathgate RA, et al., Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem. 2002 Jan 11;277(2):1148-57
(Latest) J:181534 Smith CM, et al., Relaxin-3 null mutation mice display a circadian hypoactivity phenotype. Genes Brain Behav. 2012 Feb;11(1):94-104
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory