Rln3
Gene Detail

Symbol Name ID

Rln3 relaxin 3 MGI:2158015

Synonyms

M3

Feature Type

protein coding gene

Genetic Map

Chromosome 8

40.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:84043067-84044979 bp, - strand From NCBI annotation of GRCm38   1913 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: relaxin-3/insulin-like peptide 5
Gene Tree: Rln3

Human homologs

Human Homolog		RLN3, relaxin 3
NCBI Gene ID		117579
neXtProt AC		NX_Q8WXF3
Human Synonyms		H3, insl7, RXN3, ZINS4
Human Chr (Location)		19p13.2; chr19:14139017-14141783 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit abnormal body weight regulation, actvity levels, social investigation and behavioral despair.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	positive regulation of cAMP biosynthetic process
Component	extracellular region
Function	G-protein coupled receptor binding, hormone activity

External Resources: FuncBase

Expression

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(2) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000045232 (Evidence)
Entrez Gene	212108 (Evidence)
UniGene	261583
DFCI	TC1651902
DoTS	DT.101354193
NIA Mouse Gene Index	U057340
Consensus CDS Project	CCDS22466.1
International Mouse Knockout Project Status	Rln3

Sequences

Length	Strain/Species
genomic	212108	NCBI Gene Model | MGI Sequence Detail	1913	C57BL/6J
transcript	NM_173184	RefSeq | MGI Sequence Detail	475	Not Specified
polypeptide	Q8CHK2	UniProt | EBI | MGI Sequence Detail	141	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
Protein Ontology	PR:000014035	relaxin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:73691 Bathgate RA, et al., Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem. 2002 Jan 11;277(2):1148-57
(Latest) J:181534 Smith CM, et al., Relaxin-3 null mutation mice display a circadian hypoactivity phenotype. Genes Brain Behav. 2012 Feb;11(1):94-104
All references(31)