Vac14
Gene Detail

Symbol Name ID

Vac14 Vac14 homolog (S. cerevisiae) MGI:2157980

Synonyms

D8Wsu151e, ingls, MGC:38230, Tax1bp2, Trx

Feature Type

protein coding gene

Genetic Map

Chromosome 8

57.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:110618638-110720396 bp, + strand From Ensembl annotation of GRCm38   101759 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Vac14

Human homologs

Human Homolog		VAC14, Vac14 homolog (S. cerevisiae)
NCBI Gene ID		55697
neXtProt AC		NX_Q08AM6
Human Synonyms		ArPIKfyve, TAX1BP2, TRX
Human Chr (Location)		16q22.1; chr16:70721342-70835061 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(7) Spontaneous(1)
 

Mice homozygous for a null mutation display early postnatal lethality with lesions in multiple regions of the brain. Mice homozygous for a hypomorphic allele exhibit postnatal lethality, spongiform degeneration, enlarged brain ventricles and coat color dilution.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cell death, positive regulation of catalytic activity, ...
Component	endoplasmic reticulum, endosome, ...
Function	kinase activator activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (3)    Images (1)
Theiler Stages: 11, 23

Assay Type	Results
RNA in situ	1
RT-PCR	6

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(15) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000010936 (Evidence)
Entrez Gene	234729 (Evidence)
DFCI	TC1572996, TC1591991, TC1596492, TC1773339, TC1778344
DoTS	DT.101180964, DT.101203126, DT.101234632, DT.101359177, DT.101737312, DT.534402, DT.55116813, DT.91407409
NIA Mouse Gene Index	U009822
Consensus CDS Project	CCDS22663.1
International Mouse Knockout Project Status	Vac14

Sequences

Length	Strain/Species
genomic	ENSMUSG00000010936	Ensembl Gene Model | MGI Sequence Detail	101759	C57BL/6J
transcript	ENSMUST00000034190	Ensembl | MGI Sequence Detail	3028	Not Applicable
polypeptide	ENSMUSP00000034190	Ensembl | MGI Sequence Detail	782	Not Applicable

All sequences(89) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(266 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR021841	Vacuolar protein 14 C-terminal Fig4-binding domain
InterPro	IPR026825	Vacuole morphology and inheritance protein 14
Protein Ontology	PR:000017247	protein VAC14

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:190368 Zolov SN, et al., In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17472-7
All references(45)

Other accession IDs

MGD-MRK-35755, MGI:107290, MGI:2142449, MGI:2159426, MGI:2384587