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Vac14
Gene Detail
Symbol

Name
ID
Vac14
Vac14 homolog (S. cerevisiae)
MGI:2157980
Synonyms
D8Wsu151e, ingls, MGC:38230, Tax1bp2, Trx
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:110618638-110720396 bp, + strand
From Ensembl annotation of GRCm38

  101759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vac14

Human
homologs
Human Homolog VAC14, Vac14 homolog (S. cerevisiae)
NCBI Gene ID 55697
neXtProt AC  NX_Q08AM6
Human Synonyms  ArPIKfyve, TAX1BP2, TRX
Human Chr (Location)  16q22.1; chr16:70687439-70801171 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display early postnatal lethality with lesions in multiple regions of the brain. Mice homozygous for a hypomorphic allele exhibit postnatal lethality, spongiform degeneration, enlarged brain ventricles and coat color dilution.
 
Phenotype Images(2)
Interactions
Vac14 interacts with 111 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of catalytic activity, positive regulation of phosphorylation, ...
Component endoplasmic reticulum, endosome, ...
Function kinase activator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 6
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(1) cDNA(90) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000010936 (Evidence)
Entrez Gene234729 (Evidence)
UniGene274894
DFCITC1572996, TC1591991, TC1773339, TC1596492, TC1778344
DoTSDT.101180964, DT.101203126, DT.101234632, DT.91407409, DT.55116813, DT.534402, DT.101359177, DT.101737312
NIA Mouse Gene IndexU009822
Consensus CDS ProjectCCDS22663.1
International Mouse Knockout Project StatusVac14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010936 Ensembl Gene Model | MGI Sequence Detail 101759 C57BL/6J ±  kb
transcript ENSMUST00000034190 Ensembl | MGI Sequence Detail 3028 Not Applicable 
polypeptide ENSMUSP00000034190 Ensembl | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(7) UniProt(9)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021841 Vacuolar protein 14 C-terminal Fig4-binding domain
InterPro IPR026825 Vacuole morphology and inheritance protein 14
Protein Ontology PR:000017247 protein VAC14
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:210019 Cai X, et al., PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol. 2014 Apr 1;192(7):3383-9
All references(49)
Other
accession IDs
MGD-MRK-35755, MGI:107290, MGI:2142449, MGI:2159426, MGI:2384587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory