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Vac14 Gene Detail
Summary
  • Symbol
    Vac14
  • Name
    Vac14 homolog (S. cerevisiae)
  • Synonyms
    D8Wsu151e, ingls, MGC:38230, Tax1bp2, Trx
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157980
    NCBI Gene: 234729
  • Gene Overview
    MyGene.info: VAC14
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:110618585-110720398 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101814 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.59 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    VAC14, Vac14, PIKFYVE complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VAC14, Vac14, PIKFYVE complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ArPIKfyve, TAX1BP2, TRX
  • Links
    NCBI Gene ID: 55697
    neXtProt AC: NX_Q08AM6
    UniProt: Q08AM6

  • Chr Location
    16q22.1-q22.2; chr16:70687439-70801169 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6528
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VAC14
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early postnatal lethality with lesions in multiple regions of the brain. Mice homozygous for a hypomorphic allele exhibit postnatal lethality, spongiform degeneration, enlarged brain ventricles and coat color dilution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061893 VEGA Gene Model | MGI Sequence Detail 101814 C57BL/6J ±  kb
    transcript OTTMUST00000151039 VEGA | MGI Sequence Detail 3069 Not Applicable  
    polypeptide OTTMUSP00000078330 VEGA | MGI Sequence Detail 782 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      277 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 1
      cDNA 90
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35755, MGI:107290, MGI:2142449, MGI:2159426, MGI:2384587
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:236650 Li X, et al., A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat Cell Biol. 2016 Apr;18(4):404-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory