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Vac14 Gene Detail
Summary
  • Symbol
    Vac14
  • Name
    Vac14 homolog (S. cerevisiae)
  • Synonyms
    D8Wsu151e, ingls, MGC:38230, Tax1bp2, Trx
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157980
    NCBI Gene: 234729
  • Gene Overview
    MyGene.info: VAC14
Location & Maps
more
  • Sequence Map
    Chr8:110618638-110720396 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101759 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.59 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    VAC14, Vac14, PIKFYVE complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VAC14, Vac14, PIKFYVE complex component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ArPIKfyve, TAX1BP2, TRX
  • Links
    NCBI Gene ID: 55697
    neXtProt AC: NX_Q08AM6

  • Chr Location
    16q22.1; chr16:70687439-70801166 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6528
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VAC14
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    7
  • Spontaneous
    1
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a null mutation display early postnatal lethality with lesions in multiple regions of the brain. Mice homozygous for a hypomorphic allele exhibit postnatal lethality, spongiform degeneration, enlarged brain ventricles and coat color dilution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010936 Ensembl Gene Model | MGI Sequence Detail 101759 C57BL/6J ±  kb
transcript ENSMUST00000034190 Ensembl | MGI Sequence Detail 3028 Not Applicable  
polypeptide ENSMUSP00000034190 Ensembl | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    277 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017247 protein VAC14
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR021841 Vacuolar protein 14 C-terminal Fig4-binding domain
    IPR026825 Vacuole morphology and inheritance protein 14
    IPR032878 Vacuole morphology and inheritance protein 14, Fab1-binding region
Molecular
Reagents
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  • All nucleic 92
    Genomic 1
    cDNA 90
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35755, MGI:107290, MGI:2142449, MGI:2159426, MGI:2384587
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:218853 Cao M, et al., Upregulation of Parkin in endophilin mutant mice. J Neurosci. 2014 Dec 3;34(49):16544-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory