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Cd209d Gene Detail
Summary
  • Symbol
    Cd209d
  • Name
    CD209d antigen
  • Synonyms
    mSIGNR3, SIGNR3, SIGN-R3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157947
    NCBI Gene: 170779
  • Gene Overview
    MyGene.info: CD209
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3871824-3878548 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157947
protein coding gene Chr8:3871824-3878555 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033320
protein coding gene Chr8:850962-857947 (-)
A/J MGP_AJ_G0033303
protein coding gene Chr8:791188-797916 (-)
AKR/J MGP_AKRJ_G0033234
protein coding gene Chr8:820899-827627 (-)
BALB/cJ MGP_BALBcJ_G0033303
protein coding gene Chr8:836036-842743 (-)
C3H/HeJ MGP_C3HHeJ_G0033017
protein coding gene Chr8:825265-831992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033813
protein coding gene Chr8:890284-897036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030785
protein coding gene Chr8:742668-749454 (-)
CAST/EiJ MGP_CASTEiJ_G0032340
protein coding gene Chr8:760877-768494 (-)
CBA/J MGP_CBAJ_G0032990
protein coding gene Chr8:901611-908314 (-)
DBA/2J MGP_DBA2J_G0033144
protein coding gene Chr8:760801-768390 (-)
FVB/NJ MGP_FVBNJ_G0033091
protein coding gene Chr8:806075-814473 (-)
LP/J MGP_LPJ_G0033236
protein coding gene Chr8:803235-810396 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033126
protein coding gene Chr8:880428-888364 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033831
protein coding gene Chr8:809121-815841 (-)
PWK/PhJ MGP_PWKPhJ_G0032050
protein coding gene Chr8:753042-760184 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031894
protein coding gene Chr8:780809-787468 (-)
WSB/EiJ MGP_WSBEiJ_G0032453
protein coding gene Chr8:802953-810503 (-)



Homology
more
  • Human Ortholog
    CD209, CD209 molecule
  • Vertebrate Orthologs
    3
  • Human Ortholog
    CD209, CD209 molecule
    Orthology source: HGNC
  • Synonyms
    CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
  • Links
    NCBI Gene ID: 30835
    neXtProt AC: NX_Q9NNX6
    UniProt: Q9NNX6

  • Chr Location
    19p13.2; chr19:7739993-7747609 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human CD209 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal susceptibility to bacterial infection despite decreased T and B cell proliferation and extramedullary hematopoiesis in the spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170779 NCBI Gene Model | MGI Sequence Detail 6725 C57BL/6J ±  kb
transcript NM_130904 RefSeq | MGI Sequence Detail 880 C57BL/6  
polypeptide Q91ZW8 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:72165 Park CG, et al., Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001 Oct;13(10):1283-90
  • Latest
    J:245020 Lightfoot YL, et al., SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J. 2015 Apr 01;34(7):881-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory