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Cd209a Gene Detail
Summary
  • Symbol
    Cd209a
  • Name
    CD209a antigen
  • Synonyms
    CD209, CIRE, Dcsign, DC-SIGN, DC-SIGN1, SIGNR5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157942
    NCBI Gene: 170786
Location & Maps
more
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CD209, CD209 molecule
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CD209, CD209 molecule
    Orthology source: HGNC
  • Synonyms
    CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
  • Links
    NCBI Gene ID: 30835
    neXtProt AC: NX_Q9NNX6

  • Chr Location
    19p13; chr19:7739988-7747605 (-)  GRCh38.p2

  • Human Ortholog
    CLEC4M, C-type lectin domain family 4 member M
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD209L, CD299, DC-SIGN2, DCSIGNR, DC-SIGNR, HP10347, LSIGN, L-SIGN
  • Links
    NCBI Gene ID: 10332
    neXtProt AC: NX_Q9H2X3

  • Chr Location
    19p13; chr19:7763054-7770558 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human CD209 associations

Human Disease Mouse Models
       Dengue Virus, Susceptibility to   OMIM: 614371
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal susceptibility to bacterial infection despite altered lymphocyte numbers and increased inflammatory response..
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059324 VEGA Gene Model | MGI Sequence Detail 5588 C57BL/6J ±  kb
transcript OTTMUST00000145622 VEGA | MGI Sequence Detail 1482 Not Applicable  
polypeptide OTTMUSP00000075867 VEGA | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:20938 Katz LC, Somatosensory development. A new level of refinement. Curr Biol. 1994 Sep 1;4(9):831-4
  • Latest
    J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory