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Cdhr1 Gene Detail
Summary
  • Symbol
    Cdhr1
  • Name
    cadherin-related family member 1
  • Synonyms
    Pcdh21, Prcad
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157782
    NCBI Gene: 170677
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:37077849-37098311 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20463 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 21.29 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDHR1, cadherin related family member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDHR1, cadherin related family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CORD15, PCDH21, PRCAD, RP65
  • Links
    NCBI Gene ID: 92211
    neXtProt AC: NX_Q96JP9
    UniProt: Q96JP9

  • Chr Location
    10q23.1; chr10:84194635-84219621 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 13215
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDHR1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CDHR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit progressive degeneration of retinal photoreceptor cells and a slight reduction in light responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170677 NCBI Gene Model | MGI Sequence Detail 20463 C57BL/6J ±  kb
    transcript NM_130878 RefSeq | MGI Sequence Detail 4400 C57BL/6  
    polypeptide Q8VHP6 UniProt | EBI | MGI Sequence Detail 859 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      293 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 71
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:73286 Rattner A, et al., A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron. 2001 Dec 6;32(5):775-86
    • Latest
      J:256152 Wang Y, et al., The Auxiliary Calcium Channel Subunit alpha2delta4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron. 2017 Mar 22;93(6):1359-1374.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory