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Recql5 Gene Detail
Summary
  • Symbol
    Recql5
  • Name
    RecQ protein-like 5
  • Synonyms
    Recq5b, Recql5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156841
    NCBI Gene: 170472
  • Gene Overview
    MyGene.info: RECQL5
Location & Maps
more
  • Sequence Map
    Chr11:115892595-115933477 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40883 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RECQL5, RecQ like helicase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RECQL5, RecQ like helicase 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RECQ5
  • Links
    NCBI Gene ID: 9400
    neXtProt AC: NX_O94762

  • Chr Location
    17q25; chr17:75626845-75667191 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene express elevated levels of sister chromatid exchange due to a failure to suppress crossovers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003617 VEGA Gene Model | MGI Sequence Detail 40883 C57BL/6J ±  kb
transcript OTTMUST00000007806 VEGA | MGI Sequence Detail 3971 Not Applicable  
polypeptide OTTMUSP00000003793 VEGA | MGI Sequence Detail 982 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    300 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013862 ATP-dependent DNA helicase Q5
  • EC
  • InterPro Domains
    IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain
    IPR011545 DEAD/DEAH box helicase domain
    IPR004589 DNA helicase, ATP-dependent, RecQ type
    IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR010716 RecQ helicase-like 5
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 5
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:73673 Ohhata T, et al., Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Gene. 2001 Dec 12;280(1-2):59-66
  • Latest
    J:223244 Kim TM, et al., RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. Nucleic Acids Res. 2015 Jan;43(2):893-903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory