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Slc2a10 Gene Detail
Summary
  • Symbol
    Slc2a10
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 10
  • Synonyms
    Glut10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156687
    NCBI Gene: 170441
  • Gene Overview
    MyGene.info: SLC2A10
Location & Maps
more
  • Sequence Map
    Chr2:165503787-165519917 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16131 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC2A10, solute carrier family 2 member 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC2A10, solute carrier family 2 member 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATS, GLUT10
  • Links
    NCBI Gene ID: 81031
    neXtProt AC: NX_O95528

  • Chr Location
    20q13.1; chr20:46708347-46736347 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Slc2a10 mouse models; 1 with human SLC2A10 associations

Human Disease Mouse Models
       Arterial Tortuosity Syndrome; ATS   OMIM: 208050 View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (ENU)
    2
  • Incidental Mutations
    APF
Mice carrying ENU-induced mutations in this gene display thickening and aberrant vessel wall shape of large and medium size arteries, with significantly increased elastic fiber number and size. Cerebral arteries appear normal with no evidence of tortuosity, stenosis/dilatation or aneurysm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001114 VEGA Gene Model | MGI Sequence Detail 16131 C57BL/6J ±  kb
transcript OTTMUST00000002184 VEGA | MGI Sequence Detail 3544 Not Applicable  
polypeptide OTTMUSP00000001065 VEGA | MGI Sequence Detail 536 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015059 solute carrier family 2, facilitated glucose transporter member 10
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR003663 Sugar/inositol transporter
    IPR005829 Sugar transporter, conserved site
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1858383
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:49040 Herron BJ, et al., Putative assignment of ESTs to the genetic map by use of the SSLP database. Mamm Genome. 1998 Dec;9(12):1072-4
  • Latest
    J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory