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Gpha2 Gene Detail
Summary
  • Symbol
    Gpha2
  • Name
    glycoprotein hormone alpha 2
  • Synonyms
    GPA2, zsig51
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156541
    NCBI Gene: 170458
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6276431-6277798 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.35 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156541
 protein coding gene Chr19:6276410-6277798 (+)
129S1/SvImJ ENSMUSG00200043603
 protein coding gene Chr19:3038844-3040232 (+)
A/J ENSMUSG00195049328
 protein coding gene Chr19:3446638-3448026 (+)
AKR/J ENSMUSG00220049454
 protein coding gene Chr19:3212641-3214029 (+)
BALB/cJ ENSMUSG00180042338
 protein coding gene Chr19:3814223-3815611 (+)
C3H/HeJ ENSMUSG00175011445
 protein coding gene Chr19:3064386-3065774 (+)
C57BL/6NJ ENSMUSG00215044859
 protein coding gene Chr19:3277190-3278578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022600
 protein coding gene Chr19:3011470-3012661 (+)
CAST/EiJ ENSTCUG00005042847
 protein coding gene Chr19:3197161-3198543 (+)
CBA/J ENSMUSG00210040868
 protein coding gene Chr19:3067105-3068538 (+)
DBA/2J ENSMUSG00185044788
 protein coding gene Chr19:3443581-3445014 (+)
FVB/NJ ENSMUSG00205049823
 protein coding gene Chr19:3445521-3446948 (+)
JF1/MsJ ENSUMUG00000013917
 protein coding gene Chr19:3413065-3414410 (+)
LP/J ENSMUSG00230053025
 protein coding gene Chr19:4345711-4347099 (+)
NOD/ShiLtJ ENSMUSG00190024048
 protein coding gene Chr19:2973959-2975347 (+)
NZO/HlLtJ ENSMUSG00225025462
 protein coding gene Chr19:8054523-8055911 (+)
PWK/PhJ ENSLUMG00010004060
 protein coding gene Chr19:3179572-3180917 (+)
SPRET/EiJ ENSMSPG00010047679
 protein coding gene Chr19:3174880-3176150 (+)
WSB/EiJ ENSIUOG00005040772
 protein coding gene Chr19:3087107-3088536 (+)



Homology
more
  • Human Ortholog
    GPHA2, glycoprotein hormone subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPHA2, glycoprotein hormone subunit alpha 2
  • Synonyms
    A2, GPA2, ZSIG51
  • Links
    NCBI Gene ID: 170589
    UniProt: Q96T91

  • Chr Location
    11q13.1; chr11:64934471-64937708 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170458 NCBI Gene Model | MGI Sequence Detail 1368 C57BL/6J ±  kb
transcript NM_130453 RefSeq | MGI Sequence Detail 624 C57BL/6  
polypeptide Q925Q5 UniProt | EBI | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 5
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:77753 Hsu SY, et al., Evolution of Glycoprotein Hormone Subunit Genes in Bilateral Metazoa: Identification of Two Novel Human Glycoprotein Hormone Subunit Family Genes, GPA2 and GPB5. Mol Endocrinol. 2002 Jul;16(7):1538-51
  • Latest
    J:346056 Ge X, et al., Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling. Mol Cell Endocrinol. 2024 Jan 20;586:112163
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory