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Gphb5 Gene Detail
Summary
  • Symbol
    Gphb5
  • Name
    glycoprotein hormone beta 5
  • Synonyms
    Gpb5, OGH, Zlut1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156540
    NCBI Gene: 217674
  • Gene Overview
    MyGene.info: GPHB5
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:75411722-75416781 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 32.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156540
protein coding gene Chr12:75411720-75416781 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019847
protein coding gene Chr12:75419107-75424162 (-)
A/J MGP_AJ_G0019805
protein coding gene Chr12:72598946-72604007 (-)
AKR/J MGP_AKRJ_G0019780
protein coding gene Chr12:74795828-74800887 (-)
BALB/cJ MGP_BALBcJ_G0019784
protein coding gene Chr12:73070008-73075069 (-)
C3H/HeJ MGP_C3HHeJ_G0019590
protein coding gene Chr12:75261169-75266232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020236
protein coding gene Chr12:77789581-77794642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017854
protein coding gene Chr12:69947589-69952564 (-)
CAST/EiJ MGP_CASTEiJ_G0019141
protein coding gene Chr12:70032761-70037806 (-)
CBA/J MGP_CBAJ_G0019560
protein coding gene Chr12:80774176-80779237 (-)
DBA/2J MGP_DBA2J_G0019676
protein coding gene Chr12:72467873-72472932 (-)
FVB/NJ MGP_FVBNJ_G0019663
protein coding gene Chr12:71285452-71290498 (-)
LP/J MGP_LPJ_G0019748
protein coding gene Chr12:75438925-75443984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019702
protein coding gene Chr12:83843757-83848816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020272
protein coding gene Chr12:74274100-74279161 (-)
PWK/PhJ MGP_PWKPhJ_G0018907
protein coding gene Chr12:66811089-66816264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018701
protein coding gene Chr12:68754126-68758980 (-)
WSB/EiJ MGP_WSBEiJ_G0019193
protein coding gene Chr12:74866027-74871094 (-)



Homology
more
  • Human Ortholog
    GPHB5, glycoprotein hormone beta 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPHB5, glycoprotein hormone beta 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B5, GPB5, ZLUT1
  • Links
    NCBI Gene ID: 122876
    neXtProt AC: NX_Q86YW7
    UniProt: Q86YW7

  • Chr Location
    14q23.2; chr14:63312835-63318879 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18476
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPHB5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice do not display any gross malformations and have normal body weight, composition, and metabolic parameters.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048982 Ensembl Gene Model | MGI Sequence Detail 5060 C57BL/6J ±  kb
transcript ENSMUST00000051079 Ensembl | MGI Sequence Detail 1612 Not Applicable  
polypeptide ENSMUSP00000061488 Ensembl | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 28
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:96633 Macdonald LE, et al., Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501
  • Latest
    J:226954 Bassett JH, et al., Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. Endocrinology. 2015 Sep;156(9):3098-113

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory