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Elovl6 Gene Detail
Summary
  • Symbol
    Elovl6
  • Name
    ELOVL family member 6, elongation of long chain fatty acids (yeast)
  • Synonyms
    FEN1/Elo2, SUR4/Elo3-like, LCE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156528
    NCBI Gene: 170439
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129532386-129638495 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156528
protein coding gene Chr3:129532355-129638495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027870
protein coding gene Chr3:132193009-132297133 (+)
A/J MGP_AJ_G0027828
protein coding gene Chr3:127606501-127712663 (+)
AKR/J MGP_AKRJ_G0027793
protein coding gene Chr3:130912962-131018730 (+)
BALB/cJ MGP_BALBcJ_G0027841
protein coding gene Chr3:127444021-127549604 (+)
C3H/HeJ MGP_C3HHeJ_G0027570
protein coding gene Chr3:131302128-131407760 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028285
protein coding gene Chr3:136930382-137046029 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025623
protein coding gene Chr3:123130060-123236963 (+)
CAST/EiJ MGP_CASTEiJ_G0027027
protein coding gene Chr3:130969502-131089384 (+)
CBA/J MGP_CBAJ_G0027546
protein coding gene Chr3:141553990-141659614 (+)
DBA/2J MGP_DBA2J_G0027687
protein coding gene Chr3:126795783-126901588 (+)
FVB/NJ MGP_FVBNJ_G0027654
protein coding gene Chr3:124372244-124478631 (+)
LP/J MGP_LPJ_G0027796
protein coding gene Chr3:133709139-133815568 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027685
protein coding gene Chr3:149499178-149601042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028342
protein coding gene Chr3:130574419-130688143 (+)
PWK/PhJ MGP_PWKPhJ_G0026751
protein coding gene Chr3:126524808-126632076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026576
protein coding gene Chr3:128637032-128744178 (+)
WSB/EiJ MGP_WSBEiJ_G0027106
protein coding gene Chr3:131283590-131392355 (+)



Homology
more
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FACE, FAE, LCE
  • Links
    NCBI Gene ID: 79071
    neXtProt AC: NX_Q9H5J4
    UniProt: Q9H5J4

  • Chr Location
    4q25; chr4:110049073-110199199 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11456
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELOVL6
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap mutation exhibit enhanced motor coordination. Female homozygotes exhibit decreased serum cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170439 NCBI Gene Model | MGI Sequence Detail 106110 C57BL/6J ±  kb
    transcript NM_130450 RefSeq | MGI Sequence Detail 5951 C57BL/6  
    polypeptide Q920L5 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      cDNA 169
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140052
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:274867 Lim M, et al., Haemoglobin expression in in vivo murine preimplantation embryos suggests a role in oxygen-regulated gene expression. Reprod Fertil Dev. 2019 Apr;31(4):724-734

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory