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Elovl6 Gene Detail
Summary
  • Symbol
    Elovl6
  • Name
    ELOVL family member 6, elongation of long chain fatty acids (yeast)
  • Synonyms
    FEN1/Elo2, SUR4/Elo3-like, LCE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156528
    NCBI Gene: 170439
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:129532355-129638495 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106141 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ELOVL6, ELOVL fatty acid elongase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FACE, FAE, LCE
  • Links
    NCBI Gene ID: 79071
    neXtProt AC: NX_Q9H5J4
    UniProt: Q9H5J4

  • Chr Location
    4q25; chr4:110049073-110199199 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11456
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELOVL6
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null gene trap mutation exhibit enhanced motor coordination. Female homozygotes exhibit decreased serum cholesterol levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054039 VEGA Gene Model | MGI Sequence Detail 106141 C57BL/6J ±  kb
    transcript OTTMUST00000134317 VEGA | MGI Sequence Detail 2610 Not Applicable  
    polypeptide OTTMUSP00000071246 VEGA | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      656 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      cDNA 168
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140052
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2017;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory