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Slc7a12 Gene Detail
Summary
  • Symbol
    Slc7a12
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
  • Synonyms
    Asc-2, asc-type amino acid transporter 2, XAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156159
    NCBI Gene: 140918
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14480697-14505819 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 3.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156159
protein coding gene Chr3:14480697-14505830 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027072
protein coding gene Chr3:11591972-11626458 (+)
A/J MGP_AJ_G0027036
protein coding gene Chr3:11595248-11621901 (+)
AKR/J MGP_AKRJ_G0027006
protein coding gene Chr3:11581536-11608863 (+)
BALB/cJ MGP_BALBcJ_G0027045
protein coding gene Chr3:11322908-11351754 (+)
C3H/HeJ MGP_C3HHeJ_G0026785
protein coding gene Chr3:11904841-11931914 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027489
protein coding gene Chr3:12402222-12429822 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024851
protein coding gene Chr3:9924955-9949964 (+)
CAST/EiJ MGP_CASTEiJ_G0026243
protein coding gene Chr3:11903091-11925237 (+)
CBA/J MGP_CBAJ_G0026763
protein coding gene Chr3:12592856-12625845 (+)
DBA/2J MGP_DBA2J_G0026899
protein coding gene Chr3:11167136-11192774 (+)
FVB/NJ MGP_FVBNJ_G0026866
protein coding gene Chr3:10990687-11016317 (+)
LP/J MGP_LPJ_G0027009
protein coding gene Chr3:12165067-12191224 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026887
protein coding gene Chr3:14334192-14384038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027549
protein coding gene Chr3:11395934-11421559 (+)
PWK/PhJ MGP_PWKPhJ_G0025978
protein coding gene Chr3:11279201-11305050 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025781
protein coding gene Chr3:11432906-11461450 (+)
WSB/EiJ MGP_WSBEiJ_G0026314
protein coding gene Chr3:11453781-11480013 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 140918 NCBI Gene Model | MGI Sequence Detail 25123 C57BL/6J ±  kb
transcript NM_080852 RefSeq | MGI Sequence Detail 1730 C57BL/6  
polypeptide NP_543128 RefSeq | MGI Sequence Detail 465 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR002293 Amino acid/polyamine transporter I
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 13

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:73570 Chairoungdua A, et al., Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. J Biol Chem. 2001 Dec 28;276(52):49390-9
  • Latest
    J:242224 Haller M, et al., Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017 May 09;114(19):4981-4986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory