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Il25
Gene Detail
Symbol

Name
ID
Il25
interleukin 25
MGI:2155888
Synonyms
Il17e, IL-17E
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:54932695-54935837 bp, + strand
From Ensembl annotation of GRCm38

  3143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-17
Gene Tree: Il25

Human
homologs
Human Homolog IL25, interleukin 25
NCBI Gene ID 64806
neXtProt AC  NX_Q9H293
Human Synonyms  IL17E
Human Chr (Location)  14q11.2; chr14:23372809-23376403 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have increased susceptibility to parasitic infection. Male homozygous mutant mice exhibit notably increased mean serum triglyceride levels in another null allele.
 
Interactions
Il25 interacts with 98 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process eosinophil differentiation, inflammatory response, ...
Function cytokine activity, interleukin-17E receptor binding
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040770 (Evidence)
Entrez Gene140806 (Evidence)
DFCITC1695342
DoTSDT.94145468
NIA Mouse Gene IndexU015638
Consensus CDS ProjectCCDS36926.1
International Mouse Knockout Project StatusIl25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040770 Ensembl Gene Model | MGI Sequence Detail 3143 C57BL/6J ±  kb
transcript ENSMUST00000037863 Ensembl | MGI Sequence Detail 1064 Not Applicable 
polypeptide ENSMUSP00000039641 Ensembl | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010345 Interleukin-17
Protein Ontology PR:000001113 interleukin-17E
References
(Earliest) J:72821 Pan G, et al., Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice. J Immunol. 2001 Dec 1;167(11):6559-67
(Latest) J:210323 Van Dyken SJ, et al., Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity. 2014 Mar 20;40(3):414-24
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory