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Il25 Gene Detail
Summary
  • Symbol
    Il25
  • Name
    interleukin 25
  • Synonyms
    Il17e, IL-17E
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155888
    NCBI Gene: 140806
  • Gene Overview
    MyGene.info: IL25
Location & Maps
more
  • Sequence Map
    Chr14:54932695-54935837 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3143 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.00 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL25, interleukin 25
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL25, interleukin 25
    Orthology source: HomoloGene
  • Synonyms
    IL17E
  • Links
    NCBI Gene ID: 64806
    neXtProt AC: NX_Q9H293

  • Chr Location
    14q11.2; chr14:23372809-23376403 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    1 involving Il25
  • Incidental Mutations
Mice homozygous for a null allele have increased susceptibility to parasitic infection. Male homozygous mutant mice exhibit notably increased mean serum triglyceride levels in another null allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040770 Ensembl Gene Model | MGI Sequence Detail 3143 C57BL/6J ±  kb
transcript ENSMUST00000037863 Ensembl | MGI Sequence Detail 1064 Not Applicable  
polypeptide ENSMUSP00000039641 Ensembl | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR010345 Interleukin-17 family
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:72821 Pan G, et al., Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice. J Immunol. 2001 Dec 1;167(11):6559-67
  • Latest
    J:230945 Asada Y, et al., Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5194-202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory