Il25 MGI Mouse Gene Detail - MGI:2155888

Symbol

Il25
Name

interleukin 25
Synonyms

Il17e, IL-17E

Feature Type

protein coding gene
IDs

MGI:2155888
NCBI Gene: 140806
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:55170152-55173294 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.00 cM
Mapping Data

1 experiment

SNPs within 2kb

125 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155888	protein coding gene	Chr14:55170152-55173294 (+)
129S1/SvImJ	ENSMUSG00200039507	protein coding gene	Chr14:43750548-43753689 (+)
A/J	ENSMUSG00195027603	protein coding gene	Chr14:43974888-43978029 (+)
AKR/J	ENSMUSG00220025569	protein coding gene	Chr14:43302820-43305961 (+)
BALB/cJ	ENSMUSG00180051100	protein coding gene	Chr14:43598623-43601764 (+)
C3H/HeJ	ENSMUSG00175047145	protein coding gene	Chr14:45281012-45284153 (+)
C57BL/6NJ	ENSMUSG00215045377	protein coding gene	Chr14:43493258-43496400 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019280	protein coding gene	Chr14:46363877-46367085 (+)
CAST/EiJ	ENSTCUG00005047925	protein coding gene	Chr14:45278982-45282116 (+)
CBA/J	ENSMUSG00210036522	protein coding gene	Chr14:43961517-43964658 (+)
DBA/2J	ENSMUSG00185049599	protein coding gene	Chr14:49020786-49023927 (+)
FVB/NJ	ENSMUSG00205024605	protein coding gene	Chr14:43358363-43361504 (+)
JF1/MsJ	ENSUMUG00000032818	protein coding gene	Chr14:60259641-60262783 (+)
LP/J	ENSMUSG00230052351	protein coding gene	Chr14:61116448-61119589 (+)
NOD/ShiLtJ	ENSMUSG00190039458	protein coding gene	Chr14:43719285-43722426 (+)
NZO/HlLtJ	ENSMUSG00225048746	protein coding gene	Chr14:51414574-51417715 (+)
PWK/PhJ	ENSLUMG00010040021	protein coding gene	Chr14:43184298-43187439 (+)
SPRET/EiJ	ENSMSPG00010035347	protein coding gene	Chr14:46581726-46584888 (+)
WSB/EiJ	ENSIUOG00005034926	protein coding gene	Chr14:43183410-43186551 (+)

Human Ortholog

IL25, interleukin 25

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL25, interleukin 25
Synonyms

IL17E
Links

HGNC:13765

NCBI Gene ID: 64806

UniProt: Q9H293
Chr Location

14q11.2; chr14:23372809-23376403 (+) GRCh38

MGI Vertebrate Homology

Il25 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL25
Gene Tree

Il25

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Phenotype Summary

39 phenotypes from 6 alleles in 7 genetic backgrounds
2 phenotypes from multigenic genotypes
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

8
Targeted

9
Genomic Mutations

1 involving Il25
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele have increased susceptibility to parasitic infection. Male homozygous mutant mice exhibit notably increased mean serum triglyceride levels in another null allele.

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All GO Annotations

17
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS36926.1

Ensembl

ENSMUSG00000040770 (Evidence)
NCBI Gene

140806

			Length	Strain/Species	Flank
genomic	140806	NCBI Gene Model \| MGI Sequence Detail	3143	C57BL/6J	± kb
transcript	NM_080729	RefSeq \| MGI Sequence Detail	1064	C57BL/6
polypeptide	Q8VHH8	UniProt \| EBI \| MGI Sequence Detail	169	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001113 interleukin-25

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR010345 Interleukin-17 family
GlyGen

Q8VHH8 1 site

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All nucleic 5

Genomic 1

cDNA 4

Microarray probesets 3

Summaries

All 124

Gene Ontology 10

Phenotypes 61
Earliest

J:72821 Pan G, et al., Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice. J Immunol. 2001 Dec 1;167(11):6559-67
Latest

J:373974 Cortez VS, et al., IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity. Cell. 2025 Sep 3;

TSS for Il25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125681	Chr14:55170501-55170513 (+)	355 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24