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Wdr5 Gene Detail
Summary
  • Symbol
    Wdr5
  • Name
    WD repeat domain 5
  • Synonyms
    2410008O07Rik, Big-3, Bmp2-induced gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155884
    NCBI Gene: 140858
  • Gene Overview
    MyGene.info: WDR5
Location & Maps
more
  • Sequence Map
    Chr2:27515157-27536535 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21379 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WDR5, WD repeat domain 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR5, WD repeat domain 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIG-3, CFAP89, SWD3
  • Links
    NCBI Gene ID: 11091
    neXtProt AC: NX_P61964
    UniProt: P61964

  • Chr Location
    9q34.2; chr9:134135679-134159972 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 59931
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WDR5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012048 VEGA Gene Model | MGI Sequence Detail 21379 C57BL/6J ±  kb
transcript OTTMUST00000028670 VEGA | MGI Sequence Detail 2890 Not Applicable  
polypeptide OTTMUSP00000012976 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    cDNA 141

    Microarray probesets 4
Other
Accession IDs
less
MGI:1922060, MGI:2138759, MGI:2138815
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 16
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:238097 Kikani CK, et al., Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife. 2016 Sep 23;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory