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P2ry14 Gene Detail
Summary
  • Symbol
    P2ry14
  • Name
    purinergic receptor P2Y, G-protein coupled, 14
  • Synonyms
    A330108O13Rik, Gpr105, P2Y14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155705
    NCBI Gene: 140795
  • Gene Overview
    MyGene.info: P2RY14
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59114623-59153492 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 28.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155705
protein coding gene Chr3:59113855-59153618 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027243
protein coding gene Chr3:57989215-58030066 (-)
A/J MGP_AJ_G0027203
protein coding gene Chr3:56174528-56214303 (-)
AKR/J MGP_AKRJ_G0027173
protein coding gene Chr3:57342578-57382060 (-)
BALB/cJ MGP_BALBcJ_G0027216
protein coding gene Chr3:55981540-56021290 (-)
C3H/HeJ MGP_C3HHeJ_G0026959
protein coding gene Chr3:57565600-57605813 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027662
protein coding gene Chr3:60129560-60171070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025016
protein coding gene Chr3:52524001-52568212 (-)
CAST/EiJ MGP_CASTEiJ_G0026411
protein coding gene Chr3:57734361-57773857 (-)
CBA/J MGP_CBAJ_G0026935
protein coding gene Chr3:62117204-62156836 (-)
DBA/2J MGP_DBA2J_G0027069
protein coding gene Chr3:55684493-55724133 (-)
FVB/NJ MGP_FVBNJ_G0027037
protein coding gene Chr3:54637092-54676732 (-)
LP/J MGP_LPJ_G0027181
protein coding gene Chr3:58747069-58787623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027055
protein coding gene Chr3:66263861-66304553 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027720
protein coding gene Chr3:57310523-57350798 (-)
PWK/PhJ MGP_PWKPhJ_G0026143
protein coding gene Chr3:55312262-55353652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025956
protein coding gene Chr3:57008196-57053702 (-)
WSB/EiJ MGP_WSBEiJ_G0026485
protein coding gene Chr3:57387465-57427667 (-)



Homology
more
  • Human Ortholog
    P2RY14, purinergic receptor P2Y14
  • Vertebrate Orthologs
    9
  • Human Ortholog
    P2RY14, purinergic receptor P2Y14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPR105, GPR105, P2Y14
  • Links
    NCBI Gene ID: 9934
    neXtProt AC: NX_Q15391
    UniProt: Q15391

  • Chr Location
    3q25.1; chr3:151212115-151279165 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele fail to exhibit increased glucose mediated forestomach muscle tension. Mice homozygous for a different null allele show decreased gastrointestinal emptying, impaired glucose tolerance, decreased glucose-stimulated insulin release, and reduced airway responsiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 140795 NCBI Gene Model | MGI Sequence Detail 38870 C57BL/6J ±  kb
transcript NM_001287123 RefSeq | MGI Sequence Detail 1994 C57BL/6  
polypeptide Q9ESG6 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR005466 P2Y14 purinoceptor
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2441794
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:113918 Chambers JK, et al., A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000 Apr 14;275(15):10767-71
  • Latest
    J:254511 Inoue K, et al., The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017 May 2;19(5):949-956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory