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Nt5c1a Gene Detail
Summary
  • Symbol
    Nt5c1a
  • Name
    5'-nucleotidase, cytosolic IA
  • Synonyms
    Cn1a, LOC230718
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155700
    NCBI Gene: 230718
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123201504-123216275 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155700
protein coding gene Chr4:123201204-123225339 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028737
protein coding gene Chr4:124628159-124642934 (+)
A/J MGP_AJ_G0028696
protein coding gene Chr4:119763756-119778566 (+)
AKR/J MGP_AKRJ_G0028649
protein coding gene Chr4:122999492-123014256 (+)
BALB/cJ MGP_BALBcJ_G0028718
protein coding gene Chr4:120347154-120361921 (+)
C3H/HeJ MGP_C3HHeJ_G0028434
protein coding gene Chr4:123110351-123125118 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029160
protein coding gene Chr4:129444950-129459719 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026433
protein coding gene Chr4:112982638-112997343 (+)
CAST/EiJ MGP_CASTEiJ_G0027865
protein coding gene Chr4:121132634-121147449 (+)
CBA/J MGP_CBAJ_G0028399
protein coding gene Chr4:132725693-132740563 (+)
DBA/2J MGP_DBA2J_G0028548
protein coding gene Chr4:120267092-120281856 (+)
FVB/NJ MGP_FVBNJ_G0028515
protein coding gene Chr4:118885062-118899846 (+)
LP/J MGP_LPJ_G0028649
protein coding gene Chr4:124904874-124919685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028541
protein coding gene Chr4:137670377-137685151 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029198
protein coding gene Chr4:123377967-123392730 (+)
PWK/PhJ MGP_PWKPhJ_G0027587
protein coding gene Chr4:116659540-116674528 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027413
protein coding gene Chr4:119184789-119203964 (+)
WSB/EiJ MGP_WSBEiJ_G0027945
protein coding gene Chr4:123451492-123468374 (+)



Homology
more
  • Human Ortholog
    NT5C1A, 5'-nucleotidase, cytosolic IA
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NT5C1A, 5'-nucleotidase, cytosolic IA
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CN1, CN1A, CNI, CN-I, CN-IA
  • Links
    NCBI Gene ID: 84618
    neXtProt AC: NX_Q9BXI3
    UniProt: Q9BXI3

  • Chr Location
    1p34.2; chr1:39659121-39672038 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 57173
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NT5C1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Nt5c1a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054958 Ensembl Gene Model | MGI Sequence Detail 14772 C57BL/6J ±  kb
transcript ENSMUST00000068262 Ensembl | MGI Sequence Detail 1220 Not Applicable  
polypeptide ENSMUSP00000069422 Ensembl | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 2
    cDNA 6
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2684895
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:245800 Kviklyte S, et al., Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E48-E62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory