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Myh7
Gene Detail
Symbol

Name
ID
Myh7
myosin, heavy polypeptide 7, cardiac muscle, beta
MGI:2155600
Synonyms
beta-MHC, B-MHC, MYH-beta/slow, Myhcb, Myhc-b, MyHC-I
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:54970688-54994634 bp, - strand
From VEGA annotation of GRCm38

  23947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 10 zebrafish

HCOP human homology predictions: MYH7
Gene Tree: Myh7

Human
homologs
MYH7, myosin, heavy chain 7, cardiac muscle, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4625
neXtProt AC: NX_P12883

Human Synonyms: CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM

Human Chr (Location): 14q12; chr14:23412738-23435686 (-)  GRCh38.p2

Disease Associations: (7) Diseases Associated with Human MYH7

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Myh7 interacts with 49 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process adult heart development, ATP metabolic process, ...
Component cytoplasm, focal adhesion, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (112 records)
Data Summary: Results (101)    Tissues (32)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 17
Northern blot 9
Western blot 20
RT-PCR 54
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYH7 ; Xenbase LOC100485637    NEW 
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(18) Primer pair(11) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016385 (Evidence)
Ensembl Gene Model ENSMUSG00000053093 (Evidence)
Entrez Gene 140781 (Evidence)
DoTS DT.55281492, DT.97346749, DT.99869373, DT.99871595
Consensus CDS Project CCDS27106.1
International Mouse Phenotyping Consortium Status Myh7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016385 VEGA Gene Model | MGI Sequence Detail 23947 C57BL/6J ±  kb
transcript OTTMUST00000039449 VEGA | MGI Sequence Detail 6139 Not Applicable 
polypeptide OTTMUSP00000017626 VEGA | MGI Sequence Detail 1935 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)    SNPs within 2kb including multiple locations(388)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010830 myosin-7
References
(Earliest) J:32287 Sassoon D, et al., Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature. 1989 Sep 28;341(6240):303-7
(Latest) J:220106 Zhang P, et al., Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem Biophys Res Commun. 2014 Sep 12;452(1):53-9
All references(156)
Other
accession IDs
MGD-MRK-12742, MGD-MRK-12744, MGI:97256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory