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Myh7
Gene Detail
 Symbol
Name
ID
Myh7
myosin, heavy polypeptide 7, cardiac muscle, beta
MGI:2155600
Synonyms beta-MHC, B-MHC, MYH-beta/slow, Myhcb, Myhc-b, MyHC-I
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:54970688-54994634 bp, - strand
From VEGA annotation of GRCm38

  23947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 10 zebrafish

Gene Tree: Myh7

Human
homologs
Human Homolog MYH7, myosin, heavy chain 7, cardiac muscle, beta
NCBI Gene ID 4625
neXtProt AC  NX_P12883
Human Synonyms  CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM
Human Chr (Location)  14q12; chr14:23412738-23435661 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human MYH7
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Myh7 interacts with 50 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process adult heart development, ATP catabolic process, ...
Component cytoplasm, focal adhesion, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (100 records)
Data Summary: Results (101)    Tissues (32)    Images (21)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 17
Northern blot 9
Western blot 20
RT-PCR 54
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(18) Primer pair(11) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016385 (Evidence)
Ensembl Gene ModelENSMUSG00000053093 (Evidence)
Entrez Gene140781 (Evidence)
Consensus CDS ProjectCCDS27106.1
International Mouse Knockout Project StatusMyh7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016385 VEGA Gene Model | MGI Sequence Detail 23947 C57BL/6J ±  kb
transcript OTTMUST00000039449 VEGA | MGI Sequence Detail 6139 Not Applicable 
polypeptide OTTMUSP00000017626 VEGA | MGI Sequence Detail 1935 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(378 from dbSNP Build 137)    SNPs within 2kb including multiple locations(388)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010830 myosin-7
References (Earliest) J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
(Latest) J:202826 Kasahara A, et al., Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science. 2013 Nov 8;342(6159):734-7
All references(141)
Other
accession IDs
MGD-MRK-12742, MGD-MRK-12744, MGI:97256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory