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Myh7 Gene Detail
Summary
  • Symbol
    Myh7
  • Name
    myosin, heavy polypeptide 7, cardiac muscle, beta
  • Synonyms
    betaMHC, beta-MHC, B-MHC, MYH-beta/slow, Myhcb, Myhc-b, MyHC-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155600
    NCBI Gene: 140781
  • Gene Overview
    MyGene.info: MYH7
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54970684-54994549 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155600
protein coding gene Chr14:54970684-54994626 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021335
protein coding gene Chr14:48956583-48986862 (-)
A/J MGP_AJ_G0021294
protein coding gene Chr14:47990125-48013707 (-)
AKR/J MGP_AKRJ_G0021271
protein coding gene Chr14:49757860-49759692 (-)
BALB/cJ MGP_BALBcJ_G0021298
protein coding gene Chr14:47966473-47991195 (-)
C3H/HeJ MGP_C3HHeJ_G0021078
protein coding gene Chr14:49430002-49453544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021736
protein coding gene Chr14:51430588-51464175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019283
protein coding gene Chr14:46401639-46425271 (-)
CAST/EiJ MGP_CASTEiJ_G0020597
protein coding gene Chr14:45668595-45696632 (-)
CBA/J MGP_CBAJ_G0021045
protein coding gene Chr14:52991685-53023910 (-)
DBA/2J MGP_DBA2J_G0021166
protein coding gene Chr14:47731209-47754697 (-)
FVB/NJ MGP_FVBNJ_G0021148
protein coding gene Chr14:47193916-47220953 (-)
LP/J MGP_LPJ_G0021240
protein coding gene Chr14:50021255-50035360 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021172
protein coding gene Chr14:52373596-52400460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021763
protein coding gene Chr14:48916875-48948398 (-)
PWK/PhJ MGP_PWKPhJ_G0020344
protein coding gene Chr14:44268096-44293106 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020172
protein coding gene Chr14:44898771-44924904 (-)
WSB/EiJ MGP_WSBEiJ_G0020650
protein coding gene Chr14:49211671-49239817 (-)



Homology
more
  • Human Ortholog
    MYH7, myosin heavy chain 7
  • Vertebrate Orthologs
    18
  • Human Ortholog
    MYH7, myosin heavy chain 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM
  • Links
    NCBI Gene ID: 4625
    neXtProt AC: NX_P12883
    UniProt: P12883

  • Chr Location
    14q11.2; chr14:23412738-23435686 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human MYH7 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 1 genetic background
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140781 NCBI Gene Model | MGI Sequence Detail 23866 C57BL/6J ±  kb
    transcript NM_001361607 RefSeq | MGI Sequence Detail 6313 C57BL/6  
    polypeptide Q91Z83 UniProt | EBI | MGI Sequence Detail 1935 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 2
      cDNA 20
      Primer pair 12
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12742, MGD-MRK-12744, MGI:97256
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 150
      Diseases 1
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
    • Latest
      J:263025 Zoupa M, et al., Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory