Rem2 MGI Mouse Gene Detail - MGI:2155260 - rad and gem related GTP binding protein 2

Symbol

Rem2
Name

rad and gem related GTP binding protein 2

Feature Type

protein coding gene
IDs

MGI:2155260
NCBI Gene: 140743
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:54713676-54717889 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.80 cM
Mapping Data

2 experiments

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155260	protein coding gene	Chr14:54713557-54717889 (+)
129S1/SvImJ	ENSMUSG00200039560	protein coding gene	Chr14:43292879-43297188 (+)
A/J	ENSMUSG00195032990	protein coding gene	Chr14:43517166-43521475 (+)
AKR/J	ENSMUSG00220026805	protein coding gene	Chr14:42845135-42849445 (+)
BALB/cJ	ENSMUSG00180050896	protein coding gene	Chr14:43140930-43145240 (+)
C3H/HeJ	ENSMUSG00175046314	protein coding gene	Chr14:44823357-44827666 (+)
C57BL/6NJ	ENSMUSG00215047909	protein coding gene	Chr14:43035954-43040285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019257	protein coding gene	Chr14:45906381-45910690 (+)
CAST/EiJ	ENSTCUG00005044125	protein coding gene	Chr14:44827856-44832178 (+)
CBA/J	ENSMUSG00210042420	protein coding gene	Chr14:43503891-43508200 (+)
DBA/2J	ENSMUSG00185052562	protein coding gene	Chr14:48550749-48555086 (+)
FVB/NJ	ENSMUSG00205024534	protein coding gene	Chr14:42892970-42897303 (+)
JF1/MsJ	ENSUMUG00000042988	protein coding gene	Chr14:59807212-59811551 (+)
LP/J	ENSMUSG00230051847	protein coding gene	Chr14:60658833-60663143 (+)
NOD/ShiLtJ	ENSMUSG00190030381	protein coding gene	Chr14:43253898-43258231 (+)
NZO/HlLtJ	ENSMUSG00225049967	protein coding gene	Chr14:50956938-50961247 (+)
PWK/PhJ	ENSLUMG00010042463	protein coding gene	Chr14:42726803-42731112 (+)
SPRET/EiJ	ENSMSPG00010037793	protein coding gene	Chr14:46131855-46136196 (+)
WSB/EiJ	ENSIUOG00005034221	protein coding gene	Chr14:42719095-42723403 (+)

Human Ortholog

REM2, RRAD and GEM like GTPase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REM2, RRAD and GEM like GTPase 2
Links

HGNC:20248

NCBI Gene ID: 161253

UniProt: Q8IYK8
Chr Location

14q11.2; chr14:22883136-22887686 (+) GRCh38

MGI Vertebrate Homology

Rem2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REM2
Gene Tree

Rem2

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Phenotype Summary

10 phenotypes from 2 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Rem2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit strain-specific impaired viability and fertility as well as altered intrinsic excitability and spontaneous firing in visual circuits.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

639
Tissues

8
cDNA Data

6
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rem2

ZFIN rem2

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All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS27090.2

Ensembl

ENSMUSG00000022176 (Evidence)
NCBI Gene

140743

			Length	Strain/Species	Flank
genomic	140743	NCBI Gene Model \| MGI Sequence Detail	4214	C57BL/6J	± kb
transcript	NM_080726	RefSeq \| MGI Sequence Detail	1766	C57BL/6
polypeptide	Q8VEL9	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013882 GTP-binding protein REM 2

(term hierarchy)
PDB

3Q85
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR051641 RGK GTP-binding regulators

IPR025662 Sigma-54 interaction domain, ATP-binding site 1

IPR001806 Small GTPase
GlyGen

Q8VEL9 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

cDNA 6

Microarray probesets 6

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MGI:2145812

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 9
Earliest

J:56855 Finlin BS, et al., Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. Arch Biochem Biophys. 1999 Aug 15;368(2):401-12
Latest

J:366865 Santiago C, et al., Activity-dependent development of the body's touch receptors. Neuron. 2025 May 13;

TSS for Rem2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125658	Chr14:54713640-54713647 (+)	-32 bp
Tssr125659	Chr14:54713669-54713685 (+)	1 bp
Tssr4412	Chr14:54713703-54713716 (+)	34 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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