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Gpr6
Gene Detail
 Symbol
Name
ID
Gpr6
G protein-coupled receptor 6
MGI:2155249
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:41070493-41071584 bp, - strand
From NCBI annotation of GRCm38

  1092 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr6

Human
homologs
Human Homolog GPR6, G protein-coupled receptor 6
NCBI Gene ID 2830
neXtProt AC  NX_P46095
Human Chr (Location)  6q21; chr6:109978256-109980720 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not appear to result in a phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (193)    Tissues (125)    Images (33)
Theiler Stages: 10, 18, 19, 23, 25, 26, 28
Assay TypeResults
RNA in situ 93
In situ reporter (knock in) 42
Northern blot 8
RT-PCR 50
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(5) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046922 (Evidence)
Entrez Gene140741 (Evidence)
DFCITC1599369, TC1679659
DoTSDT.91403840
NIA Mouse Gene IndexU048652
Consensus CDS ProjectCCDS23802.1
International Mouse Knockout Project StatusGpr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 140741 NCBI Gene Model | MGI Sequence Detail 1092 C57BL/6J ±  kb
transcript NM_199058 RefSeq | MGI Sequence Detail 1092 C57BL/6 
polypeptide Q6YNI2 UniProt | EBI | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000723 G protein-coupled receptor 3/6/12 orphan
InterPro IPR001151 G protein-coupled receptor 6
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001674 G-protein coupled receptor 6
Graphical View of Protein Domain Structure
References (Earliest) J:72844 Chalhoub N, et al., Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21. Mamm Genome. 2001 Dec;12(12):887-92
(Latest) J:206284 Lu KM, et al., Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
All references(36)
Other
accession IDs
MGI:2143693, MGI:2685079

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory