Gpr6
Gene Detail

Symbol Name ID

Gpr6 G protein-coupled receptor 6 MGI:2155249

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:41070493-41071584 bp, - strand From NCBI annotation of GRCm38   1092 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38026  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPR6-like G protein-coupled receptor
Gene Tree: Gpr6

Human homologs

Human Homolog		GPR6, G protein-coupled receptor 6
NCBI Gene ID		2830
neXtProt AC		NX_P46095
Human Chr (Location)		6q21; chr6:110300298-110301923 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutation of this gene does not appear to result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (144)    Tissues (76)    Images (31)
Theiler Stages: 10, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	44
In situ reporter (knock in)	42
Northern blot	8
RT-PCR	50

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(5) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000046922 (Evidence)
Entrez Gene	140741 (Evidence)
DFCI	TC1599369, TC1679659
DoTS	DT.91403840
NIA Mouse Gene Index	U048652
Consensus CDS Project	CCDS23802.1
International Mouse Knockout Project Status	Gpr6

Sequences

Length	Strain/Species
genomic	140741	NCBI Gene Model | MGI Sequence Detail	1092	C57BL/6J
transcript	NM_199058	RefSeq | MGI Sequence Detail	1092	C57BL/6
polypeptide	Q6YNI2	UniProt | EBI | MGI Sequence Detail	363	Not Applicable

All sequences(18) RefSeq(3) UniProt(2)

Polymorphisms

SNPs within 2kb(29 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000723	G protein-coupled receptor 3/6/12 orphan
InterPro	IPR001151	G protein-coupled receptor 6
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001674	sphingosine 1-phosphate receptor GPR6

Graphical View of Protein Domain Structure

References

(Earliest) J:72844 Chalhoub N, et al., Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21. Mamm Genome. 2001 Dec;12(12):887-92
(Latest) J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
All references(34)

Other accession IDs

MGI:2143693, MGI:2685079