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Map4k3 Gene Detail
Summary
  • Symbol
    Map4k3
  • Name
    mitogen-activated protein kinase kinase kinase kinase 3
  • Synonyms
    4833416M07Rik, 9530052P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154405
    NCBI Gene: 225028
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80580512-80728093 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 50.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154405
protein coding gene Chr17:80580512-80728205 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024066
protein coding gene Chr17:83522016-83674374 (-)
A/J MGP_AJ_G0024023
protein coding gene Chr17:80974382-81120649 (-)
AKR/J MGP_AKRJ_G0023992
protein coding gene Chr17:82230513-82388905 (-)
BALB/cJ MGP_BALBcJ_G0024025
protein coding gene Chr17:80826571-80975432 (-)
C3H/HeJ MGP_C3HHeJ_G0023789
protein coding gene Chr17:83089532-83239205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024469
protein coding gene Chr17:86556353-86705000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021910
protein coding gene Chr17:76299340-76455526 (-)
CAST/EiJ MGP_CASTEiJ_G0023269
protein coding gene Chr17:83779696-83933246 (-)
CBA/J MGP_CBAJ_G0023763
protein coding gene Chr17:90177400-90340062 (-)
DBA/2J MGP_DBA2J_G0023892
protein coding gene Chr17:79447757-79595349 (-)
FVB/NJ MGP_FVBNJ_G0023858
protein coding gene Chr17:78947058-79094578 (-)
LP/J MGP_LPJ_G0023975
protein coding gene Chr17:84364717-84516283 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023886
protein coding gene Chr17:90210105-90371691 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024514
protein coding gene Chr17:82708918-82869928 (-)
PWK/PhJ MGP_PWKPhJ_G0023015
protein coding gene Chr17:79005632-79158633 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022826
protein coding gene Chr17:79501221-79657575 (-)
WSB/EiJ MGP_WSBEiJ_G0023336
protein coding gene Chr17:83538714-83696434 (-)



Homology
more
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GLK, MAPKKKK3, MEKKK3, MEKKK 3, RAB8IPL1
  • Links
    NCBI Gene ID: 8491
    neXtProt AC: NX_Q8IVH8
    UniProt: Q8IVH8

  • Chr Location
    2p22.1; chr2:39249266-39437312 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased susceptibility to experimental autoimmune encephalomyelitis, decreased stimulated immunoglobin production, decreased stimulated T cell proliferation, and abnormal Th1, Th2, and Th17 differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024242 Ensembl Gene Model | MGI Sequence Detail 147582 C57BL/6J ±  kb
    transcript ENSMUST00000112389 Ensembl | MGI Sequence Detail 4231 Not Applicable  
    polypeptide ENSMUSP00000108008 Ensembl | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR001180 Citron homology (CNH) domain
      IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926112
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory