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Map4k3 Gene Detail
Summary
  • Symbol
    Map4k3
  • Name
    mitogen-activated protein kinase kinase kinase kinase 3
  • Synonyms
    4833416M07Rik, 9530052P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154405
    NCBI Gene: 225028
Location & Maps
more
  • Sequence Map
    Chr17:80580512-80728093 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      147582 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 50.97 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP4K3, mitogen-activated protein kinase kinase kinase kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GLK, MAPKKKK3, MEKKK3, MEKKK 3, RAB8IPL1
  • Links
    NCBI Gene ID: 8491
    neXtProt AC: NX_Q8IVH8

  • Chr Location
    2p22.1; chr2:39249266-39437312 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    70
  • Gene trapped
    68
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit decreased susceptibility to experimental autoimmune encephalomyelitis, decreased stimulated immunoglobin production, decreased stimulated T cell proliferation, and abnormal Th1, Th2, and Th17 differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024242 Ensembl Gene Model | MGI Sequence Detail 147582 C57BL/6J ±  kb
transcript ENSMUST00000112389 Ensembl | MGI Sequence Detail 4231 Not Applicable  
polypeptide ENSMUSP00000108008 Ensembl | MGI Sequence Detail 896 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1166 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010145 mitogen-activated protein kinase kinase kinase kinase 3
  • EC
  • InterPro Domains
    IPR001180 Citron homology (CNH) domain
    IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1926112
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:177642 Chuang HC, et al., The kinase GLK controls autoimmunity and NF-kappaB signaling by activating the kinase PKC-theta in T cells. Nat Immunol. 2011;12(11):1113-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory