About   Help   FAQ
Ankrd6 Gene Detail
Summary
  • Symbol
    Ankrd6
  • Name
    ankyrin repeat domain 6
  • Synonyms
    diversin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154278
    NCBI Gene: 140577
Location & Maps
more
  • Sequence Map
    Chr4:32804035-32950841 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      146807 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 14.42 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ANKRD6, ankyrin repeat domain 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKRD6, ankyrin repeat domain 6
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 22881
    neXtProt AC: NX_Q9Y2G4

  • Chr Location
    6q15; chr6:89433178-89633834 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8967
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANKRD6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    131
  • Chemically and radiation induced
    1
  • Gene trapped
    127
  • Targeted
    3
  • Genomic Mutations
    1 involving Ankrd6
  • Incidental Mutations
Mice homozygous for a null mutation display sporadic disruption of utricle hair cell polarity but normal cochlear and vestibular hair cell morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004975 VEGA Gene Model | MGI Sequence Detail 146807 C57BL/6J ±  kb
transcript OTTMUST00000011049 VEGA | MGI Sequence Detail 4683 Not Applicable  
polypeptide OTTMUSP00000005164 VEGA | MGI Sequence Detail 712 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    852 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 47
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:78250 Tissir F, et al., Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Dev Dyn. 2002 Aug;224(4):465-9
  • Latest
    J:216288 Jones C, et al., Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. Dev Biol. 2014 Nov 1;395(1):62-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory