Plxnd1
Gene Detail

Symbol

Name
ID

Plxnd1
plexin D1
MGI:2154244

Synonyms

6230425C21Rik, b2b1863Clo, b2b553Clo

Feature Type

protein coding gene

Genetic Map

Chromosome 6
53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:115954811-115995005 bp, - strand From VEGA annotation of GRCm38   40195 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:22866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plxnd1

Human
homologs

Human Homolog		PLXND1, plexin D1
NCBI Gene ID		23129
neXtProt AC		NX_Q9Y4D7
Human Synonyms		PLEXD1
Human Chr (Location)		3q22.1; chr3:129555213-129606739 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Chemically induced (ENU)(2) Spontaneous(1) Targeted(6)
Genomic Mutations involving Plxnd1 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels.

 
Human Diseases Modeled in Mice Using Plxnd1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(32)

Interactions

Plxnd1 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (27 annotations)

Process	angiogenesis, dichotomous subdivision of terminal units involved in salivary gland branching, ...
Component	integral component of membrane, integral component of plasma membrane, ...
Function	protein binding, protein domain specific binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)

Data Summary: Results (66)    Tissues (40)    Images (36)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	58
Northern blot	8

cDNA source data(94)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(96) cDNA(95) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000021239 (Evidence)
Ensembl Gene Model	ENSMUSG00000030123 (Evidence)
Entrez Gene	67784 (Evidence)
UniGene	3085
DFCI	TC1587092, TC1581885, TC1597035, TC1600030
DoTS	DT.110474064, DT.97360480, DT.531787
Consensus CDS Project	CCDS20448.1
International Mouse Knockout Project Status	Plxnd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021239	VEGA Gene Model | MGI Sequence Detail	40195	C57BL/6J
transcript	OTTMUST00000050306	VEGA | MGI Sequence Detail	6907	Not Applicable
polypeptide	OTTMUSP00000023467	VEGA | MGI Sequence Detail	1925	Not Applicable

All sequences(39) RefSeq(3) UniProt(6)

Polymorphisms

SNPs within 2kb(283 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR002165	Plexin
InterPro	IPR013548	Plexin, cytoplasmic RasGAP domain
InterPro	IPR016201	Plexin-like fold
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000012899	plexin-D1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(71)
Disease annotation references (1)

Other
accession IDs

MGI:1915034, MGI:5316760, MGI:5476162