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Plxnb3 Gene Detail
Summary
  • Symbol
    Plxnb3
  • Name
    plexin B3
  • Synonyms
    Plxn6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154240
    NCBI Gene: 140571
  • Gene Overview
    MyGene.info: PLXNB3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73757090-73772514 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154240
protein coding gene ChrX:73756559-73772514 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035818
protein coding gene ChrX:69531811-69547804 (+)
A/J MGP_AJ_G0035799
protein coding gene ChrX:69728439-69744704 (+)
AKR/J MGP_AKRJ_G0035724
protein coding gene ChrX:71550001-71565412 (+)
BALB/cJ MGP_BALBcJ_G0035784
protein coding gene ChrX:68760306-68776124 (+)
C3H/HeJ MGP_C3HHeJ_G0035489
protein coding gene ChrX:70005884-70021367 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036314
protein coding gene ChrX:71662513-71678352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033158
protein coding gene ChrX:68759843-68775094 (+)
CAST/EiJ MGP_CASTEiJ_G0034780
protein coding gene ChrX:55351423-55366964 (+)
CBA/J MGP_CBAJ_G0035464
protein coding gene ChrX:73641873-73657302 (+)
DBA/2J MGP_DBA2J_G0035621
protein coding gene ChrX:69187061-69202916 (+)
FVB/NJ MGP_FVBNJ_G0035565
protein coding gene ChrX:68518782-68533985 (+)
LP/J MGP_LPJ_G0035706
protein coding gene ChrX:70313874-70330379 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035603
protein coding gene ChrX:76211450-76226888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036336
protein coding gene ChrX:69353733-69369157 (+)
PWK/PhJ MGP_PWKPhJ_G0034479
protein coding gene ChrX:53366764-53383061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034313
protein coding gene ChrX:56255153-56270614 (+)
WSB/EiJ MGP_WSBEiJ_G0034921
protein coding gene ChrX:68627332-68643018 (+)



Homology
more
  • Human Ortholog
    PLXNB3, plexin B3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLXNB3, plexin B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PLEXB3, PLEXR, PLXN6
  • Links
    NCBI Gene ID: 5365
    neXtProt AC: NX_Q9ULL4
    UniProt: Q9ULL4

  • Chr Location
    Xq28; chrX:153764196-153779346 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal retinal stratification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031385 Ensembl Gene Model | MGI Sequence Detail 15425 C57BL/6J ±  kb
    transcript ENSMUST00000002079 Ensembl | MGI Sequence Detail 6030 Not Applicable  
    polypeptide ENSMUSP00000002079 Ensembl | MGI Sequence Detail 1902 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147891, MGI:2154211
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:72426 Cheng HJ, et al., Plexin-a3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001 Oct 25;32(2):249-63
    • Latest
      J:225235 Azzarelli R, et al., An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Nat Commun. 2014;5:3405

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory