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Smc1b
Gene Detail
Symbol

Name
ID
Smc1b
structural maintenance of chromosomes 1B
MGI:2154049
Synonyms
SMC1beta, Smc1l2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.25 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:85064691-85131957 bp, - strand
From Ensembl annotation of GRCm38

  67267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMC1B
Protein SuperFamily: SMC
Gene Tree: Smc1b

Human
homologs
SMC1B, structural maintenance of chromosomes 1B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27127
neXtProt AC: NX_Q8NDV3

Human Synonyms: SMC1BETA, SMC1L2

Human Chr (Location): 22q13.31; chr22:45344063-45413629 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Radiation induced(1) Spontaneous(1) Targeted(5)
Genomic Mutations involving Smc1b (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice display male and female infertility, abnormal male and female meiosis, and arrest of spematogenesis.
 
Phenotype Images(2)
Interactions
Smc1b interacts with 122 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle, chromosome organization, ...
Component chromosome, chromosome, centromeric region, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase smc1b    NEW 
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022432 (Evidence)
Entrez Gene 140557 (Evidence)
UniGene 182737
DFCI TC1585995
DoTS DT.60106653
NIA Mouse Gene Index U036495
Consensus CDS Project CCDS27718.1
International Mouse Phenotyping Consortium Status Smc1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022432 Ensembl Gene Model | MGI Sequence Detail 67267 C57BL/6J ±  kb
transcript ENSMUST00000023068 Ensembl | MGI Sequence Detail 4038 Not Applicable 
polypeptide ENSMUSP00000023068 Ensembl | MGI Sequence Detail 1248 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(518 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR003395 RecF/RecN/SMC, N-terminal
InterPro IPR010935 SMCs flexible hinge
InterPro IPR024704 Structural maintenance of chromosomes protein
Protein Ontology PR:000015270 structural maintenance of chromosomes protein 1B
References
(Earliest) J:71579 Revenkova E, et al., Novel meiosis-specific isoform of mammalian smc1. Mol Cell Biol. 2001 Oct;21(20):6984-98
(Latest) J:211664 Winters T, et al., Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion. EMBO J. 2014 Jun 2;33(11):1256-70
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory