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Strc Gene Detail
Summary
  • Symbol
    Strc
  • Name
    stereocilin
  • Synonyms
    DFNB16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153816
    NCBI Gene: 140476
  • Gene Overview
    MyGene.info: STRC
Location & Maps
more
  • Sequence Map
    Chr2:121363728-121387168 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23441 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STRC, stereocilin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STRC, stereocilin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFNB16
  • Links
    NCBI Gene ID: 161497
    neXtProt AC: NX_Q7RTU9

  • Chr Location
    15q15.3; chr15:43599243-43711486 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15401
    1 human;1 mouse;1 rat;2 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STRC
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Strc mouse models; 3 with human STRC associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 16; DFNB16   OMIM: 603720 View 1 model
       Deafness-Infertility Syndrome; DIS   OMIM: 611102
Spermatogenic Failure 7; SPGF7   OMIM: 612997
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Strc
  • Incidental Mutations
Mice homozygous for a null allele exhibit progressive hearing loss from P15 with abnormal cochlear outer hair cell stereociliary bundle morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015264 VEGA Gene Model | MGI Sequence Detail 23441 C57BL/6J ±  kb
transcript OTTMUST00000036173 VEGA | MGI Sequence Detail 5756 Not Applicable  
polypeptide OTTMUSP00000016253 VEGA | MGI Sequence Detail 1809 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    167 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:72411 Verpy E, et al., Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. Nat Genet. 2001 Nov;29(3):345-9
  • Latest
    J:212101 Kamiya K, et al., An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9307-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory