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Strc
Gene Detail
Symbol

Name
ID
Strc
stereocilin
MGI:2153816
Synonyms
DFNB16
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:121363728-121387168 bp, - strand
From VEGA annotation of GRCm38

  23441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STRC
Gene Tree: Strc

Human
homologs
STRC, stereocilin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 161497
neXtProt AC: NX_Q7RTU9

Human Synonyms: DFNB16

Human Chr (Location): 15q15.3; chr15:43599243-43711486 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human STRC

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit progressive hearing loss from P15 with abnormal cochlear outer hair cell stereociliary bundle morphology.
 
Human Diseases Modeled in Mice Using Strc (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Strc interacts with 161 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (6)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000015264 (Evidence)
Ensembl Gene Model ENSMUSG00000033498 (Evidence)
Entrez Gene 140476 (Evidence)
DFCI TC1594983
DoTS DT.97384712, DT.97396738
NIA Mouse Gene Index U023262
Consensus CDS Project CCDS16641.1
International Mouse Phenotyping Consortium Status Strc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015264 VEGA Gene Model | MGI Sequence Detail 23441 C57BL/6J ±  kb
transcript OTTMUST00000036173 VEGA | MGI Sequence Detail 5756 Not Applicable 
polypeptide OTTMUSP00000016253 VEGA | MGI Sequence Detail 1809 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026061 Stereocilin
InterPro IPR026664 Stereocilin related
Protein Ontology PR:000015777 stereocilin
References
(Earliest) J:72411 Verpy E, et al., Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. Nat Genet. 2001 Nov;29(3):345-9
(Latest) J:212101 Kamiya K, et al., An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9307-12
All references(23)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory