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Strc
Gene Detail
Symbol

Name
ID
Strc
stereocilin
MGI:2153816
Synonyms
DFNB16
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:121363728-121387168 bp, - strand
From VEGA annotation of GRCm38

  23441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Strc

Human
homologs
Human Homolog STRC, stereocilin
NCBI Gene ID 161497
neXtProt AC  NX_Q7RTU9
Human Synonyms  DFNB16
Human Chr (Location)  15q15.3; chr15:43599487-43618800 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human STRC
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit progressive hearing loss from P15 with abnormal cochlear outer hair cell stereociliary bundle morphology.
 
Human Diseases Modeled Using Mouse Strc (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Strc interacts with 162 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (26)    Tissues (6)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015264 (Evidence)
Ensembl Gene ModelENSMUSG00000033498 (Evidence)
Entrez Gene140476 (Evidence)
DFCITC1594983
DoTSDT.97384712, DT.97396738
NIA Mouse Gene IndexU023262
Consensus CDS ProjectCCDS16641.1
International Mouse Knockout Project StatusStrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015264 VEGA Gene Model | MGI Sequence Detail 23441 C57BL/6J ±  kb
transcript OTTMUST00000036173 VEGA | MGI Sequence Detail 5756 Not Applicable 
polypeptide OTTMUSP00000016253 VEGA | MGI Sequence Detail 1809 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026061 Stereocilin
InterPro IPR026664 Stereocilin related
Protein Ontology PR:000015777 stereocilin
References
(Earliest) J:72411 Verpy E, et al., Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. Nat Genet. 2001 Nov;29(3):345-9
(Latest) J:186025 Verpy E, et al., Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol. 2011 Feb 1;519(2):194-210
All references(23)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory