Strc
Gene Detail

Symbol Name ID

Strc stereocilin MGI:2153816

Synonyms

DFNB16

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:121363728-121387168 bp, - strand From VEGA annotation of GRCm38   23441 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Strc

Human homologs

Human Homolog		STRC, stereocilin
NCBI Gene ID		161497
neXtProt AC		NX_Q7RTU9
Human Synonyms		DFNB16
Human Chr (Location)		15q15.3; chr15:43891761-43910998 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human STRC

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a null allele exhibit progressive hearing loss from P15 with abnormal cochlear outer hair cell stereociliary bundle morphology.

 
Human Diseases Modeled Using Mouse Strc (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	auditory receptor cell stereocilium organization, detection of mechanical stimulus involved in sensory perception of sound, ...
Component	cell projection, cilium, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(2) cDNA(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000015264 (Evidence)
Ensembl Gene Model	ENSMUSG00000033498 (Evidence)
Entrez Gene	140476 (Evidence)
DFCI	TC1594983
DoTS	DT.97384712, DT.97396738
NIA Mouse Gene Index	U023262
Consensus CDS Project	CCDS16641.1
International Mouse Knockout Project Status	Strc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015264	VEGA Gene Model | MGI Sequence Detail	23441	C57BL/6J
transcript	OTTMUST00000036173	VEGA | MGI Sequence Detail	5756	Not Applicable
polypeptide	OTTMUSP00000016253	VEGA | MGI Sequence Detail	1809	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026061	Stereocilin
InterPro	IPR026664	Stereocilin related
Protein Ontology	PR:000015777	stereocilin

References

(Earliest) J:72411 Verpy E, et al., Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. Nat Genet. 2001 Nov;29(3):345-9
(Latest) J:186025 Verpy E, et al., Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol. 2011 Feb 1;519(2):194-210
All references(23)