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Itga10 Gene Detail
Summary
  • Symbol
    Itga10
  • Name
    integrin, alpha 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153482
    NCBI Gene: 213119
  • Gene Overview
    MyGene.info: ITGA10
Location & Maps
more
  • Sequence Map
    Chr3:96645584-96664513 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18930 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.93 cM, cytoband F2.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ITGA10, integrin subunit alpha 10
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITGA10, integrin subunit alpha 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO827
  • Links
    NCBI Gene ID: 8515
    neXtProt AC: NX_O75578

  • Chr Location
    1q21.1; chr1:145891208-145910411 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Itga10
  • Incidental Mutations
Homozygous null mice display slightly shortened long bones and amild abnormalities in ephysiseal plate morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029578 VEGA Gene Model | MGI Sequence Detail 18930 C57BL/6J ±  kb
transcript OTTMUST00000073365 VEGA | MGI Sequence Detail 5035 Not Applicable  
polypeptide OTTMUSP00000037956 VEGA | MGI Sequence Detail 1166 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 6
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:73056 Bengtsson T, et al., Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants. Matrix Biol. 2001 Dec;20(8):565-76
  • Latest
    J:203162 Ray A, et al., IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci. 2012 Jul;50(3-4):238-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory