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Tfap2d Gene Detail
Summary
  • Symbol
    Tfap2d
  • Name
    transcription factor AP-2, delta
  • Synonyms
    Tcfap2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153466
    NCBI Gene: 226896
Location & Maps
more
  • Sequence Map
    Chr1:19103022-19166346 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63325 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 6.08 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TFAP2D, transcription factor AP-2 delta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TFAP2D, transcription factor AP-2 delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TFAP2BL1
  • Links
    NCBI Gene ID: 83741
    neXtProt AC: NX_Q7Z6R9

  • Chr Location
    6p12.1; chr6:50713544-50773033 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit loss of inferior colliculus due to apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026492 VEGA Gene Model | MGI Sequence Detail 63325 C57BL/6J ±  kb
transcript OTTMUST00000065512 VEGA | MGI Sequence Detail 1761 Not Applicable  
polypeptide OTTMUSP00000032660 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    338 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031712 transcription factor AP-2-delta
  • InterPro Domains
    IPR004979 Transcription factor AP-2
    IPR013854 Transcription factor AP-2, C-terminal
Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:72398 Zhao F, et al., Cloning and characterization of a novel mouse ap-2 transcription factor, ap-2delta, with unique DNA binding and transactivation properties. J Biol Chem. 2001 Nov 2;276(44):40755-60
  • Latest
    J:227021 Mallika C, et al., Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory