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Rxfp2
Gene Detail
 Symbol
Name
ID
Rxfp2
relaxin/insulin-like family peptide receptor 2
MGI:2153463
Synonyms Gpr106, Great, LGR8
Feature Type protein coding gene
Genetic Map
Chromosome 5
89.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:150018675-150082184 bp, + strand
From VEGA annotation of GRCm38

  63510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: relaxin receptor
Gene Tree: Rxfp2

Human
homologs
Human Homolog RXFP2, relaxin/insulin-like family peptide receptor 2
NCBI Gene ID 122042
neXtProt AC  NX_Q8WXD0
Human Synonyms  GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2
Human Chr (Location)  13q13.1; chr13:31739542-31802872 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RXFP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Male homozygotes for a targeted null mutation exhibit bilateral intraabdominal cryptorchidism and sterility associated with a failure in the differentiation of the gubernaculae, ligaments that control testicular movement during development.
 
Interactions
Rxfp2 interacts with 53 markers (Mir20b, Mir22, Mir106a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, peptide hormone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (89)    Tissues (64)    Images (23)
Theiler Stages: 10, 18, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 69
Northern blot 4
RT-PCR 16
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021307 (Evidence)
Ensembl Gene ModelENSMUSG00000053368 (Evidence)
Entrez Gene140498 (Evidence)
UniGene444643
DFCITC1591097, TC1596049, TC1596534, TC1626522
DoTSDT.55208014, DT.91573537, DT.94162851, DT.94261494
NIA Mouse Gene IndexU006482
Consensus CDS ProjectCCDS19886.1
International Mouse Knockout Project StatusRxfp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021307 VEGA Gene Model | MGI Sequence Detail 63510 C57BL/6J ±  kb
transcript OTTMUST00000050517 VEGA | MGI Sequence Detail 2539 Not Applicable 
polypeptide OTTMUSP00000023592 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(6)
Polymorphisms SNPs within 2kb(823 from dbSNP Build 137)    SNPs within 2kb including multiple locations(825)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR008112 Relaxin receptor
Protein Ontology PR:000001667 relaxin receptor 2
References (Earliest) J:69948 Overbeek PA, et al., A transgenic insertion causing cryptorchidism in mice. Genesis. 2001 May;30(1):26-35
(Latest) J:194006 Huang Z, et al., Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice. Biol Reprod. 2012;87(6):143
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory