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Rxfp2 Gene Detail
Summary
  • Symbol
    Rxfp2
  • Name
    relaxin/insulin-like family peptide receptor 2
  • Synonyms
    Gpr106, Great, LGR8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153463
    NCBI Gene: 140498
Location & Maps
more
  • Sequence Map
    Chr5:150018675-150082184 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63510 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.23 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RXFP2, relaxin/insulin like family peptide receptor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RXFP2, relaxin/insulin like family peptide receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2
  • Links
    NCBI Gene ID: 122042
    neXtProt AC: NX_Q8WXD0

  • Chr Location
    13q13.1; chr13:31739542-31802872 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Rxfp2 mouse models; 1 with human RXFP2 associations

Human Disease Mouse Models
       Cryptorchidism, Unilateral or Bilateral   OMIM: 219050 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Rxfp2
  • Incidental Mutations
Male homozygotes for a targeted null mutation exhibit bilateral intraabdominal cryptorchidism and sterility associated with a failure in the differentiation of the gubernaculae, ligaments that control testicular movement during development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021307 VEGA Gene Model | MGI Sequence Detail 63510 C57BL/6J ±  kb
transcript OTTMUST00000050517 VEGA | MGI Sequence Detail 2539 Not Applicable  
polypeptide OTTMUSP00000023592 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    829 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000001667 relaxin receptor 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR008112 Relaxin receptor
Molecular
Reagents
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  • All nucleic 14
    Genomic 1
    cDNA 10
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 45
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:69948 Overbeek PA, et al., A transgenic insertion causing cryptorchidism in mice. Genesis. 2001 May;30(1):26-35
  • Latest
    J:223361 Kaftanovskaya EM, et al., Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory