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Rxfp2
Gene Detail
Symbol

Name
ID
Rxfp2
relaxin/insulin-like family peptide receptor 2
MGI:2153463
Synonyms
Gpr106, Great, LGR8
Feature Type
protein coding gene
Genetic Map
Chromosome 5
89.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:150018675-150082184 bp, + strand
From VEGA annotation of GRCm38

  63510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: RXFP2
Protein SuperFamily: relaxin receptor
Gene Tree: Rxfp2

Human
homologs
RXFP2, relaxin/insulin-like family peptide receptor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 122042
neXtProt AC: NX_Q8WXD0

Human Synonyms: GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2

Human Chr (Location): 13q13.1; chr13:31739542-31802872 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RXFP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male homozygotes for a targeted null mutation exhibit bilateral intraabdominal cryptorchidism and sterility associated with a failure in the differentiation of the gubernaculae, ligaments that control testicular movement during development.
 
Interactions
Rxfp2 interacts with 53 markers (Mir20b, Mir22, Mir106a, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (89)    Tissues (65)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Northern blot 4
RT-PCR 16
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rxfp2 ; ZFIN rxfp2a, rxfp2b    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000021307 (Evidence)
Ensembl Gene Model ENSMUSG00000053368 (Evidence)
Entrez Gene 140498 (Evidence)
UniGene 444643
DFCI TC1591097, TC1596049, TC1596534, TC1626522
DoTS DT.55208014, DT.91573537, DT.94162851, DT.94261494
NIA Mouse Gene Index U006482
Consensus CDS Project CCDS19886.1, CCDS80479.1, CCDS80480.1
International Mouse Phenotyping Consortium Status Rxfp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021307 VEGA Gene Model | MGI Sequence Detail 63510 C57BL/6J ±  kb
transcript OTTMUST00000050517 VEGA | MGI Sequence Detail 2539 Not Applicable 
polypeptide OTTMUSP00000023592 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(18) UniProt(6)
Polymorphisms
SNPs within 2kb(823 from dbSNP Build 137)    SNPs within 2kb including multiple locations(825)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR008112 Relaxin receptor
Protein Ontology PR:000001667 relaxin receptor 2
References
(Earliest) J:69948 Overbeek PA, et al., A transgenic insertion causing cryptorchidism in mice. Genesis. 2001 May;30(1):26-35
(Latest) J:223361 Kaftanovskaya EM, et al., Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB J. 2015 Jun;29(6):2327-37
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory