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Kcnn2 Gene Detail
Summary
  • Symbol
    Kcnn2
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
  • Synonyms
    bc, fri, SK2, small conductance calcium-activated potassium channel 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153182
    NCBI Gene: 140492
  • Gene Overview
    MyGene.info: KCNN2
Location & Maps
more
  • Sequence Map
    Chr18:45268860-45685883 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      417024 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.34 cM, cytoband C
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    KCNN2, potassium calcium-activated channel subfamily N member 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KCNN2, potassium calcium-activated channel subfamily N member 2
    Orthology source: HGNC
  • Synonyms
    hSK2, KCa2.2, SK2, SKCa 2, SKCA2
  • Links
    NCBI Gene ID: 3781
    neXtProt AC: NX_Q9H2S1

  • Chr Location
    5q22.3; chr5:114056006-114496500 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 14 alleles in 14 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    2
  • Spontaneous
    9
  • Targeted
    3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    6
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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  • All Sequences
    55
  • RefSeq
    8
  • UniProt
    4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044935 VEGA Gene Model | MGI Sequence Detail 417024 C57BL/6J ±  kb
transcript OTTMUST00000118103 VEGA | MGI Sequence Detail 3546 Not Applicable  
polypeptide OTTMUSP00000065954 VEGA | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1716 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000713 small conductance calcium-activated potassium channel protein 2
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1516, MGD-MRK-9871, MGI:88134, MGI:95578
References
more
  • Summaries
    All 74
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 31
  • Earliest
    J:136183 Lane PW, Bouncy (bc). Mouse News Lett. 1969;40:30
  • Latest
    J:232973 Hirst CS, et al., Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory