Kcnn2
Gene Detail

Symbol

Name
ID

Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
MGI:2153182

Synonyms

bc, fri, SK2, small conductance calcium-activated potassium channel 2

Feature Type

protein coding gene

Genetic Map

Chromosome 18
24.34 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr18:45268860-45685887 bp, + strand From VEGA annotation of GRCm38   417028 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:135651  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small/intermediate conductance calcium-activated potassium channel protein
Gene Tree: Kcnn2

Mutations,
alleles, and
phenotypes

All mutations/alleles(14) : Chemically induced (ENU)(2) Spontaneous(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology.

 

Interactions

Kcnn2 interacts with 157 markers (Mir19a, Mir19b-1, Mir19b-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (26 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	dendritic spine, integral component of membrane, ...
Function	calcium-activated potassium channel activity, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	6

cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000044935 (Evidence)
Ensembl Gene Model	ENSMUSG00000054477 (Evidence)
Entrez Gene	140492 (Evidence)
DFCI	TC1581511, TC1612271
NIA Mouse Gene Index	U018696
International Mouse Knockout Project Status	Kcnn2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044935	VEGA Gene Model | MGI Sequence Detail	417028	C57BL/6J
transcript	OTTMUST00000118103	VEGA | MGI Sequence Detail	3546	Not Applicable
polypeptide	OTTMUSP00000065954	VEGA | MGI Sequence Detail	839	Not Applicable

All sequences(52) RefSeq(8) UniProt(4)

Polymorphisms

SNPs within 2kb(1742 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1746)

Protein-related
information

Resource	ID	Description
InterPro	IPR004178	Calmodulin-binding domain
InterPro	IPR013099	Ion transport 2
InterPro	IPR015449	Potassium channel, calcium-activated, SK
Protein Ontology	PR:000000713	small conductance calcium-activated potassium channel protein 2

References

(Earliest) J:136183 Lane PW, Bouncy (bc). Mouse News Lett. 1969;40:30
(Latest) J:206606 Fuchs PA, et al., Ultrastructure of cisternal synapses on outer hair cells of the mouse cochlea. J Comp Neurol. 2014 Feb 15;522(3):717-29
All references(73)

Other
accession IDs

MGD-MRK-1516, MGD-MRK-9871, MGI:88134, MGI:95578