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Kcnn2
Gene Detail
Symbol

Name
ID
Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
MGI:2153182
Synonyms
bc, fri, SK2, small conductance calcium-activated potassium channel 2
Feature Type
protein coding gene
Genetic Map
Chromosome 18
24.34 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr18:45268860-45685883 bp, + strand
From VEGA annotation of GRCm38

  417024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135651  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small/intermediate conductance calcium-activated potassium channel protein
Gene Tree: Kcnn2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Spontaneous(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology.
 
Interactions
Kcnn2 interacts with 157 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process ion transmembrane transport, ion transport, ...
Component dendritic spine, integral component of membrane, ...
Function calcium-activated potassium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000044935 (Evidence)
Ensembl Gene ModelENSMUSG00000054477 (Evidence)
Entrez Gene140492 (Evidence)
DFCITC1581511, TC1612271
NIA Mouse Gene IndexU018696
International Mouse Knockout Project StatusKcnn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044935 VEGA Gene Model | MGI Sequence Detail 417024 C57BL/6J ±  kb
transcript OTTMUST00000118103 VEGA | MGI Sequence Detail 3546 Not Applicable 
polypeptide OTTMUSP00000065954 VEGA | MGI Sequence Detail 839 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(1742 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1746)
Protein-related
information
ResourceIDDescription
InterPro IPR004178 Calmodulin-binding domain
InterPro IPR013099 Ion transport 2
InterPro IPR015449 Potassium channel, calcium-activated, SK
Protein Ontology PR:000000713 small conductance calcium-activated potassium channel protein 2
References
(Earliest) J:136183 Lane PW, Bouncy (bc). Mouse News Lett. 1969;40:30
(Latest) J:206606 Fuchs PA, et al., Ultrastructure of cisternal synapses on outer hair cells of the mouse cochlea. J Comp Neurol. 2014 Feb 15;522(3):717-29
All references(73)
Other
accession IDs
MGD-MRK-1516, MGD-MRK-9871, MGI:88134, MGI:95578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory