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Kcnn2 Gene Detail
Summary
  • Symbol
    Kcnn2
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
  • Synonyms
    bc, fri, SK2, small conductance calcium-activated potassium channel 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153182
    NCBI Gene: 140492
  • Gene Overview
    MyGene.info: KCNN2
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:45268860-45685887 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.34 cM, cytoband C
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1716 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153182
 protein coding gene Chr18:45268860-45686024 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024403
 protein coding gene Chr18:44023894-44457507 (+)
A/J MGP_AJ_G0024370
 protein coding gene Chr18:42446493-42849710 (+)
AKR/J MGP_AKRJ_G0024339
 protein coding gene Chr18:43633576-44061491 (+)
BALB/cJ MGP_BALBcJ_G0024370
 protein coding gene Chr18:42558255-42961766 (+)
C3H/HeJ MGP_C3HHeJ_G0024137
 protein coding gene Chr18:43706633-44122274 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024814
 protein coding gene Chr18:45570975-46015856 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022249
 protein coding gene Chr18:42361824-42756060 (+)
CAST/EiJ MGP_CASTEiJ_G0023611
 protein coding gene Chr18:43655971-44067908 (+)
CBA/J MGP_CBAJ_G0024106
 protein coding gene Chr18:46800714-47247679 (+)
DBA/2J MGP_DBA2J_G0024236
 protein coding gene Chr18:42045110-42454535 (+)
FVB/NJ MGP_FVBNJ_G0024202
 protein coding gene Chr18:41663731-42064695 (+)
LP/J MGP_LPJ_G0024320
 protein coding gene Chr18:44079517-44506523 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024233
 protein coding gene Chr18:48147456-48618489 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024861
 protein coding gene Chr18:43542729-43955315 (+)
PWK/PhJ MGP_PWKPhJ_G0023355
 protein coding gene Chr18:42255226-42648127 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023160
 protein coding gene Chr18:43711275-44138092 (+)
WSB/EiJ MGP_WSBEiJ_G0023674
 protein coding gene Chr18:43438822-43851614 (+)



Homology
more
  • Human Ortholog
    KCNN2, potassium calcium-activated channel subfamily N member 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KCNN2, potassium calcium-activated channel subfamily N member 2
    Orthology source: HGNC
  • Synonyms
    hSK2, KCa2.2, SK2, SKCa 2, SKCA2
  • Links
    NCBI Gene ID: 3781
    neXtProt AC: NX_Q9H2S1
    UniProt: Q9H2S1

  • Chr Location
    5q22.3; chr5:114056006-114496500 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Kcnn2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 14 alleles in 14 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    11
  • cDNA Data
    7
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140492 NCBI Gene Model | MGI Sequence Detail 417028 C57BL/6J ±  kb
    transcript NM_001312905 RefSeq | MGI Sequence Detail 3710 C57BL/6  
    polypeptide P58390 UniProt | EBI | MGI Sequence Detail 839 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR004178 Calmodulin-binding domain
      IPR015449 Potassium channel, calcium-activated, SK
      IPR013099 Potassium channel domain
      IPR036122 SK, calmodulin-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1516, MGD-MRK-9871, MGI:88134, MGI:95578
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 13
      Phenotypes 32
    • Earliest
      J:6710 Lane PW, et al., Chromosome 18 of the house mouse. J Hered. 1981 Nov-Dec;72(6):409-12
    • Latest
      J:242595 Moruno-Manchon JF, et al., Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. Hum Mol Genet. 2017 Apr 01;26(7):1305-1317
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/06/2018
    MGI 6.13     		The Jackson Laboratory