Kcnn2 MGI Mouse Gene Detail - MGI:2153182 - potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Kcnn2 Gene Detail

Symbol

Kcnn2
Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms

bc, fri, SK2, small conductance calcium-activated potassium channel 2

Feature Type

protein coding gene
IDs

MGI:2153182
NCBI Gene: 140492
Gene Overview

MyGene.info: KCNN2

Sequence Map

Chr18:45268860-45685883 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

417024 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 24.34 cM, cytoband C
Mapping Data

10 experiments

Human Ortholog

KCNN2, potassium calcium-activated channel subfamily N member 2

Vertebrate Orthologs

6

Human Ortholog

KCNN2, potassium calcium-activated channel subfamily N member 2
Orthology source: HGNC
Synonyms

hSK2, KCa2.2, SK2, SKCa 2, SKCA2
Links

HGNC:6291

NCBI Gene ID: 3781

neXtProt AC: NX_Q9H2S1

UniProt: Q9H2S1
Chr Location

5q22.3; chr5:114056006-114496500 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 135651
1 mouse;1 rat;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KCNN2
Protein SuperFamily

small/intermediate conductance calcium-activated potassium channel protein
Gene Tree

Kcnn2

Diseases

1 with Kcnn2 mouse models

Human Disease

Mouse Models

Parkinson's disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

37 phenotypes from 14 alleles in 14 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

2
Spontaneous

9
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a point mutation exhibit tremor and gait abnormalities. Homozygous null mice lack the apamin sensitive component of the medium afterhyperpolarization current but have normal hippocampal morphology.

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All GO Annotations

27
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

6
Tissues

6
cDNA Data

7
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Kcnn2 interacts with 156 markers (Mir19a, Mir19b-1, Mir19b-2, ...) View All

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All Sequences

56
RefSeq

8
UniProt

5
CCDS

CCDS84380.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044935	VEGA Gene Model \| MGI Sequence Detail	417024	C57BL/6J	± kb
transcript	OTTMUST00000118103	VEGA \| MGI Sequence Detail	3546	Not Applicable
polypeptide	OTTMUSP00000065954	VEGA \| MGI Sequence Detail	574	Not Applicable

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SNPs within 2kb

1716 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000000713 small conductance calcium-activated potassium channel protein 2

(term hierarchy)
InterPro Domains

IPR004178 Calmodulin-binding domain

IPR015449 Potassium channel, calcium-activated, SK

IPR013099 Potassium channel domain

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 4

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MGD-MRK-1516, MGD-MRK-9871, MGI:88134, MGI:95578

Summaries

All 77

Developmental Gene Expression 3

Diseases 1

Gene Ontology 12

Phenotypes 32
Earliest

J:136183 Lane PW, Bouncy (bc). Mouse News Lett. 1969;40:30
Latest

J:234825 Grasselli G, et al., Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells. Cell Rep. 2016 Mar 22;14(11):2546-53

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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