Cspg4 MGI Mouse Gene Detail - MGI:2153093 - chondroitin sulfate proteoglycan 4

Symbol

Cspg4
Name

chondroitin sulfate proteoglycan 4
Synonyms

4732461B14Rik, AN2, NG2

Feature Type

protein coding gene
IDs

MGI:2153093
NCBI Gene: 121021
Gene Overview

MyGene.info: CSPG4
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:56865104-56899870 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.32 cM
Mapping Data

2 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153093	protein coding gene	Chr9:56865033-56899870 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034853	protein coding gene	Chr9:56023344-56058106 (+)
A/J	MGP_AJ_G0034834	protein coding gene	Chr9:54218647-54253420 (+)
AKR/J	MGP_AKRJ_G0034763	protein coding gene	Chr9:55474900-55509645 (+)
BALB/cJ	MGP_BALBcJ_G0034826	protein coding gene	Chr9:54014843-54049636 (+)
C3H/HeJ	MGP_C3HHeJ_G0034536	protein coding gene	Chr9:55938039-55972769 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035345	protein coding gene	Chr9:57596070-57630831 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032256	protein coding gene	Chr9:53558397-53593074 (+)
CAST/EiJ	MGP_CASTEiJ_G0033857	protein coding gene	Chr9:56007352-56042029 (+)
CBA/J	MGP_CBAJ_G0034507	protein coding gene	Chr9:59582276-59617037 (+)
DBA/2J	MGP_DBA2J_G0034666	protein coding gene	Chr9:54102997-54137754 (+)
FVB/NJ	MGP_FVBNJ_G0034608	protein coding gene	Chr9:53321113-53356880 (+)
LP/J	MGP_LPJ_G0034749	protein coding gene	Chr9:56310541-56345333 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034651	protein coding gene	Chr9:61082073-61118115 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035367	protein coding gene	Chr9:55477346-55512090 (+)
PWK/PhJ	MGP_PWKPhJ_G0033561	protein coding gene	Chr9:54084282-54169880 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033396	protein coding gene	Chr9:55757984-55797430 (+)
WSB/EiJ	MGP_WSBEiJ_G0033970	protein coding gene	Chr9:55415952-55450820 (+)

Human Ortholog

CSPG4, chondroitin sulfate proteoglycan 4

Vertebrate Orthologs

10

Human Ortholog

CSPG4, chondroitin sulfate proteoglycan 4
Orthology source: HomoloGene, HGNC
Synonyms

HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Links

HGNC:2466

NCBI Gene ID: 1464

neXtProt AC: NX_Q6UVK1

UniProt: Q6UVK1
Chr Location

15q24.2; chr15:75674322-75712848 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20445
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CSPG4
Gene Tree

Cspg4

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Phenotype Summary

28 phenotypes from 5 alleles in 6 genetic backgrounds
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Targeted

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

2

Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.

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All GO Annotations

25
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

226
Tissues

75
cDNA Data

46
Literature Summary

184

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cspg4

ZFIN cspg4

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Cspg4 interacts with 189 markers (Mir7b, Mir15a, Mir17, ...) View All

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS23211.1
UniGene

41329

Ensembl

ENSMUSG00000032911 (Evidence)
NCBI Gene

121021

			Length	Strain/Species	Flank
genomic	121021	NCBI Gene Model \| MGI Sequence Detail	34767	C57BL/6J	± kb
transcript	NM_139001	RefSeq \| MGI Sequence Detail	8050	C57BL/6
polypeptide	Q8VHY0	UniProt \| EBI \| MGI Sequence Detail	2327	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005953 chondroitin sulfate proteoglycan 4

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR039005 CSPG repeat

IPR001791 Laminin G domain

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All nucleic 46

cDNA 46

Microarray probesets 4

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MGI:2443606

Summaries

All 262

Developmental Gene Expression 184

Gene Ontology 9

Phenotypes 41
Earliest

J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
Latest

J:276676 Leitzen E, et al., Virus-triggered spinal cord demyelination is followed by a peripheral neuropathy resembling features of Guillain-Barre Syndrome. Sci Rep. 2019 Mar 14;9(1):4588

TSS for Cspg4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85263	Chr9:56865018-56865047 (+)	-71 bp
Tssr85264	Chr9:56865051-56865072 (+)	-42 bp
Tssr85265	Chr9:56865079-56865090 (+)	-19 bp
Tssr85266	Chr9:56865095-56865098 (+)	-7 bp
Tssr85267	Chr9:56865107-56865115 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14