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Cspg4
Gene Detail
Symbol

Name
ID
Cspg4
chondroitin sulfate proteoglycan 4
MGI:2153093
Synonyms
4732461B14Rik, AN2, NG2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
30.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:56865104-56899870 bp, + strand
From NCBI annotation of GRCm38

  34767 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSPG4
Gene Tree: Cspg4

Human
homologs
CSPG4, chondroitin sulfate proteoglycan 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1464
neXtProt AC: NX_Q6UVK1

Human Synonyms: HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Human Chr (Location): 15q24.2; chr15:75674322-75712848 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.
 
Interactions
Cspg4 interacts with 189 markers (Mir7b, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process activation of MAPK activity, angiogenesis, ...
Component cell projection, cell surface, ...
Function collagen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (123 records)
Data Summary: Results (184)    Tissues (56)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 143
Western blot 13
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cspg4 ; ZFIN cspg4    NEW 
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000032911 (Evidence)
Entrez Gene 121021 (Evidence)
UniGene 41329
DFCI TC1580720, TC1584630
DoTS DT.99714218, DT.91561392, DT.91559271, DT.491209, DT.101196426, DT.110571813
NIA Mouse Gene Index U010528
Consensus CDS Project CCDS23211.1
International Mouse Phenotyping Consortium Status Cspg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 121021 NCBI Gene Model | MGI Sequence Detail 34767 C57BL/6J ±  kb
transcript NM_139001 RefSeq | MGI Sequence Detail 8050 C57BL/6 
polypeptide Q8VHY0 UniProt | EBI | MGI Sequence Detail 2327 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005953 chondroitin sulfate proteoglycan 4
Graphical View of Protein Domain Structure
References
(Earliest) J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
(Latest) J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
All references(174)
Other
accession IDs
MGI:2443606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory