Cspg4
Gene Detail

Symbol Name ID

Cspg4 chondroitin sulfate proteoglycan 4 MGI:2153093

Synonyms

4732461B14Rik, AN2, NG2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

30.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:56865104-56899870 bp, + strand From NCBI annotation of GRCm38   34767 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cspg4

Human homologs

Human Homolog		CSPG4, chondroitin sulfate proteoglycan 4
NCBI Gene ID		1464
neXtProt AC		NX_Q6UVK1
Human Synonyms		HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Human Chr (Location)		15q24.2; chr15:75674322-75712848 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.

 

Interactions

Cspg4 interacts with 189 markers (Mir7b, Mir15a, Mir17, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	activation of MAPK activity, angiogenesis, ...
Component	cell projection, extracellular vesicular exosome, ...
Function	collagen binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (107 records)

Data Summary: Results (183)    Tissues (54)    Images (27)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	143
Western blot	13

cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(45) cDNA(45)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032911 (Evidence)
Entrez Gene	121021 (Evidence)
UniGene	41329
DFCI	TC1580720, TC1584630
DoTS	DT.101196426, DT.110571813, DT.491209, DT.91559271, DT.91561392, DT.99714218
NIA Mouse Gene Index	U010528
Consensus CDS Project	CCDS23211.1
International Mouse Knockout Project Status	Cspg4

Sequences

Length	Strain/Species
genomic	121021	NCBI Gene Model | MGI Sequence Detail	34767	C57BL/6J
transcript	NM_139001	RefSeq | MGI Sequence Detail	8050	C57BL/6
polypeptide	Q8VHY0	UniProt | EBI | MGI Sequence Detail	2327	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(192 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001791	Laminin G domain
Protein Ontology	PR:000005953	chondroitin sulfate proteoglycan 4

Graphical View of Protein Domain Structure

References

(Earliest) J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
(Latest) J:209130 Huang W, et al., Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Glia. 2014 Jun;62(6):896-913
All references(157)

Other accession IDs

MGI:2443606