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Cspg4 Gene Detail
Summary
  • Symbol
    Cspg4
  • Name
    chondroitin sulfate proteoglycan 4
  • Synonyms
    4732461B14Rik, AN2, NG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153093
    NCBI Gene: 121021
  • Gene Overview
    MyGene.info: CSPG4
Location & Maps
more
  • Sequence Map
    Chr9:56865104-56899870 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      34767 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
  • Links
    NCBI Gene ID: 1464
    neXtProt AC: NX_Q6UVK1
    UniProt: Q6UVK1

  • Chr Location
    15q24.2; chr15:75674322-75712848 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 20445
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CSPG4
  • Gene Tree
    Cspg4
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 6 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    220
  • Tissues
    73
  • cDNA Data
    45
  • Literature Summary
    149
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 121021 NCBI Gene Model | MGI Sequence Detail 34767 C57BL/6J ±  kb
transcript NM_139001 RefSeq | MGI Sequence Detail 8050 C57BL/6  
polypeptide Q8VHY0 UniProt | EBI | MGI Sequence Detail 2327 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    192 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443606
References
more
  • Summaries
    All 205
    Developmental Gene Expression 149
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
  • Latest
    J:239835 Lee S, et al., Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory