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Cspg4
Gene Detail
 Symbol
Name
ID
Cspg4
chondroitin sulfate proteoglycan 4
MGI:2153093
Synonyms 4732461B14Rik, AN2, NG2
Feature Type protein coding gene
Genetic Map
Chromosome 9
30.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:56865104-56899870 bp, + strand
From NCBI annotation of GRCm38

  34767 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cspg4

Human
homologs
Human Homolog CSPG4, chondroitin sulfate proteoglycan 4
NCBI Gene ID 1464
neXtProt AC  NX_Q6UVK1
Human Synonyms  HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Human Chr (Location)  15q24.2; chr15:75674322-75712848 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.
 
Interactions
Cspg4 interacts with 189 markers (Mir7b, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process activation of MAPK activity, angiogenesis, ...
Component cell projection, cell surface, ...
Function collagen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (111 records)
Data Summary: Results (184)    Tissues (56)    Images (27)
Theiler Stages: 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 143
Western blot 13
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032911 (Evidence)
Entrez Gene121021 (Evidence)
UniGene41329
DFCITC1580720, TC1584630
DoTSDT.101196426, DT.110571813, DT.491209, DT.91559271, DT.91561392, DT.99714218
NIA Mouse Gene IndexU010528
Consensus CDS ProjectCCDS23211.1
International Mouse Knockout Project StatusCspg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 121021 NCBI Gene Model | MGI Sequence Detail 34767 C57BL/6J ±  kb
transcript NM_139001 RefSeq | MGI Sequence Detail 8050 C57BL/6 
polypeptide Q8VHY0 UniProt | EBI | MGI Sequence Detail 2327 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005953 chondroitin sulfate proteoglycan 4
Graphical View of Protein Domain Structure
References (Earliest) J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
(Latest) J:210584 van Berlo JH, et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
All references(162)
Other
accession IDs
MGI:2443606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory