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Cspg4 Gene Detail
Summary
  • Symbol
    Cspg4
  • Name
    chondroitin sulfate proteoglycan 4
  • Synonyms
    4732461B14Rik, AN2, NG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153093
    NCBI Gene: 121021
  • Gene Overview
    MyGene.info: CSPG4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:56865104-56899870 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
  • Links
    NCBI Gene ID: 1464
    neXtProt AC: NX_Q6UVK1
    UniProt: Q6UVK1

  • Chr Location
    15q24.2; chr15:75674322-75712848 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20445
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CSPG4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 6 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 121021 NCBI Gene Model | MGI Sequence Detail 34767 C57BL/6J ±  kb
    transcript NM_139001 RefSeq | MGI Sequence Detail 8050 C57BL/6  
    polypeptide Q8VHY0 UniProt | EBI | MGI Sequence Detail 2327 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      192 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443606
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 160
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
    • Latest
      J:258230 Leferink PS, et al., Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter. Glia. 2018 Apr;66(4):862-873

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory