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Parvb
Gene Detail
 Symbol
Name
ID
Parvb
parvin, beta
MGI:2153063
Synonyms affixin, D15Gsk1
Feature Type protein coding gene
Genetic Map
Chromosome 15
39.78 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:84232043-84315688 bp, + strand
From VEGA annotation of GRCm38

  83646 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: parvin
Gene Tree: Parvb

Human
homologs
Human Homolog PARVB, parvin, beta
NCBI Gene ID 29780
neXtProt AC  NX_Q9HBI1
Human Synonyms  CGI-56
Human Chr (Location)  22q13.2-q13.33; chr22:43999211-44169233 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(32) Radiation induced(1) Targeted(3)
Genomic Mutations involving Parvb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption of this marker has no apparent adverse consequences.
 
Interactions
Parvb interacts with 214 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton reorganization, cell adhesion, ...
Component cell junction, cell projection, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (245)    Tissues (118)    Images (36)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 245
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(1) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026115 (Evidence)
Ensembl Gene ModelENSMUSG00000022438 (Evidence)
Entrez Gene170736 (Evidence)
UniGene323892
DFCITC1586282, TC1646796, TC1717315
DoTSDT.97345624
NIA Mouse Gene IndexU016505
Consensus CDS ProjectCCDS37167.1
International Mouse Knockout Project StatusParvb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026115 VEGA Gene Model | MGI Sequence Detail 83646 C57BL/6J ±  kb
transcript OTTMUST00000064489 VEGA | MGI Sequence Detail 3784 Not Applicable 
polypeptide OTTMUSP00000032032 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
Protein Ontology PR:000012304 beta-parvin
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:203427 Shibue T, et al., An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 2013 Oct 14;24(4):481-98
All references(48)
Other
accession IDs
MGI:2146041, MGI:2146245, MGI:2429856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory