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Parvb Gene Detail
Summary
  • Symbol
    Parvb
  • Name
    parvin, beta
  • Synonyms
    affixin, D15Gsk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153063
    NCBI Gene: 170736
  • Gene Overview
    MyGene.info: PARVB
Location & Maps
more
  • Sequence Map
    Chr15:84232043-84315688 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83646 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.78 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PARVB, parvin beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARVB, parvin beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-56
  • Links
    NCBI Gene ID: 29780
    neXtProt AC: NX_Q9HBI1

  • Chr Location
    22q13.2-q13.33; chr22:43999211-44169233 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8342
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PARVB
  • Protein SuperFamily
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Parvb
  • Incidental Mutations
Disruption of this marker has no apparent adverse consequences.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026115 VEGA Gene Model | MGI Sequence Detail 83646 C57BL/6J ±  kb
transcript OTTMUST00000064489 VEGA | MGI Sequence Detail 3784 Not Applicable  
polypeptide OTTMUSP00000032032 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    526 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    Genomic 1
    cDNA 52

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146041, MGI:2146245, MGI:2429856
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:203427 Shibue T, et al., An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 2013 Oct 14;24(4):481-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory