Mmp28
Gene Detail

Symbol Name ID

Mmp28 matrix metallopeptidase 28 (epilysin) MGI:2153062

Synonyms

epilysin

Feature Type

protein coding gene

Genetic Map

Chromosome 11

50.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:83440768-83463071 bp, - strand From VEGA annotation of GRCm38   22304 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp28

Human homologs

Human Homolog		MMP28, matrix metallopeptidase 28
NCBI Gene ID		79148
neXtProt AC		NX_Q9H239
Human Synonyms		EPILYSIN, MM28, MMP25, MMP-28
Human Chr (Location)		17q21.1; chr17:34092876-34122640 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(8)
 

Null homozygote mice have enhanced chemotaxis of macrophages into the lung upon infection.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	metabolic process, proteolysis
Component	cellular_component
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (22)    Images (15)
Theiler Stages: 16, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	19
RT-PCR	8

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000000928 (Evidence)
Ensembl Gene Model	ENSMUSG00000020682 (Evidence)
Entrez Gene	118453 (Evidence)
UniGene	264648
NIA Mouse Gene Index	U033191
Consensus CDS Project	CCDS25166.1, CCDS25167.1
International Mouse Knockout Project Status	Mmp28

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000928	VEGA Gene Model | MGI Sequence Detail	22304	C57BL/6J
transcript	OTTMUST00000001808	VEGA | MGI Sequence Detail	2451	Not Applicable
polypeptide	OTTMUSP00000000869	VEGA | MGI Sequence Detail	520	Not Applicable

All sequences(41) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010487	matrix metalloproteinase-28

References

(Earliest) J:72039 Illman SA, et al., Promoter characterization of the human and mouse epilysin (MMP-28) genes. Gene. 2001 Sep 5;275(1):185-94
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)