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Mmp28
Gene Detail
Symbol

Name
ID
Mmp28
matrix metallopeptidase 28 (epilysin)
MGI:2153062
Synonyms
epilysin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
50.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:83440768-83463071 bp, - strand
From VEGA annotation of GRCm38

  22304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41559  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp28

Human
homologs
Human Homolog MMP28, matrix metallopeptidase 28
NCBI Gene ID 79148
neXtProt AC  NX_Q9H239
Human Synonyms  EPILYSIN, MM28, MMP25, MMP-25, MMP-28
Human Chr (Location)  17q12; chr17:35765857-35795636 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygote mice have enhanced chemotaxis of macrophages into the lung upon infection.
 
Interactions
Mmp28 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process negative regulation of macrophage chemotaxis, proteolysis
Component cytoplasm
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (23)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RT-PCR 8
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000000928 (Evidence)
Ensembl Gene ModelENSMUSG00000020682 (Evidence)
Entrez Gene118453 (Evidence)
UniGene264648
NIA Mouse Gene IndexU033191
Consensus CDS ProjectCCDS25166.1, CCDS25167.1
International Mouse Knockout Project StatusMmp28
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000928 VEGA Gene Model | MGI Sequence Detail 22304 C57BL/6J ±  kb
transcript OTTMUST00000001808 VEGA | MGI Sequence Detail 2451 Not Applicable 
polypeptide OTTMUSP00000000869 VEGA | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010487 matrix metalloproteinase-28
References
(Earliest) J:72039 Illman SA, et al., Promoter characterization of the human and mouse epilysin (MMP-28) genes. Gene. 2001 Sep 5;275(1):185-94
(Latest) J:209547 Gharib SA, et al., MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol. 2014 Jan;95(1):9-18
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory