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Gjc3 Gene Detail
Summary
  • Symbol
    Gjc3
  • Name
    gap junction protein, gamma 3
  • Synonyms
    connexin 29, Cx29, Gje1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153041
    NCBI Gene: 118446
  • Gene Overview
    MyGene.info: GJC3
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137953461-137963098 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153041
protein coding gene Chr5:137950990-137963375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030250
protein coding gene Chr5:142743507-142752979 (-)
A/J MGP_AJ_G0030216
protein coding gene Chr5:136532730-136544936 (-)
AKR/J MGP_AKRJ_G0030151
protein coding gene Chr5:140982967-140994490 (-)
BALB/cJ MGP_BALBcJ_G0030228
protein coding gene Chr5:137920545-137930436 (-)
C3H/HeJ MGP_C3HHeJ_G0029944
protein coding gene Chr5:141627517-141638163 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030680
protein coding gene Chr5:148059096-148070192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027898
protein coding gene Chr5:130762740-130771436 (-)
CAST/EiJ MGP_CASTEiJ_G0029352
protein coding gene Chr5:141026810-141040151 (-)
CBA/J MGP_CBAJ_G0029914
protein coding gene Chr5:153937128-153953063 (-)
DBA/2J MGP_DBA2J_G0030065
protein coding gene Chr5:136461029-136470724 (-)
FVB/NJ MGP_FVBNJ_G0030020
protein coding gene Chr5:135622969-135634148 (-)
LP/J MGP_LPJ_G0030154
protein coding gene Chr5:143256974-143267820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030052
protein coding gene Chr5:156747692-156759402 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030721
protein coding gene Chr5:140829056-140839712 (-)
PWK/PhJ MGP_PWKPhJ_G0029066
protein coding gene Chr5:135523209-135533169 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028902
protein coding gene Chr5:138388774-138397868 (-)
WSB/EiJ MGP_WSBEiJ_G0029427
protein coding gene Chr5:141546247-141559457 (-)



Homology
more
  • Human Ortholog
    GJC3, gap junction protein gamma 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GJC3, gap junction protein gamma 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CX29, CX30.2, CX31.3, GJE1
  • Links
    NCBI Gene ID: 349149
    neXtProt AC: NX_Q8NFK1
    UniProt: Q8NFK1

  • Chr Location
    7q22.1; chr7:99923269-99929620 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Half of homozygotes for a null allele show delayed maturation of hearing thresholds, high-frequency hearing loss, vulnerability to noise damage and demyelination of spiral ganglion neurons. Homozygotes for another null allele show normal sciatic nerve conduction with no auditory or visual deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056966 Ensembl Gene Model | MGI Sequence Detail 9638 C57BL/6J ±  kb
transcript ENSMUST00000077119 Ensembl | MGI Sequence Detail 4002 Not Applicable  
polypeptide ENSMUSP00000076367 Ensembl | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:70957 Sohl G, et al., The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem. 2001 Jun;382(6):973-8
  • Latest
    J:167272 Parenti R, et al., Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia. 2010 Oct;58(13):1594-609

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory