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Dner
Gene Detail
Symbol

Name
ID
Dner
delta/notch-like EGF-related receptor
MGI:2152889
Synonyms
A930026D19Rik, BET, MGC:39059
Feature Type
protein coding gene
Genetic Map
Chromosome 1
43.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:84369839-84696221 bp, - strand
From VEGA annotation of GRCm38

  326383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dner

Human
homologs
Human Homolog DNER, delta/notch-like EGF repeat containing
NCBI Gene ID 92737
neXtProt AC  NX_Q8NFT8
Human Synonyms  bet, UNQ26
Human Chr (Location)  2q36.3; chr2:229357629-229714570 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display delayed cerebellar development, abnormal Bergmann glial cells, abnormal Purkinje cell innervation, and impaired coordination.
 
Interactions
Dner interacts with 216 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, glial cell differentiation, ...
Component dendrite, early endosome, ...
Function calcium ion binding, Notch binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (636)    Tissues (88)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 608
Northern blot 8
Western blot 1
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) cDNA(53)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000048002 (Evidence)
Ensembl Gene ModelENSMUSG00000036766 (Evidence)
Entrez Gene227325 (Evidence)
UniGene292560
DFCITC1575468, TC1596471
DoTSDT.87055569, DT.55255485, DT.55100478
NIA Mouse Gene IndexU021544
Consensus CDS ProjectCCDS15105.1
International Mouse Knockout Project StatusDner
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048002 VEGA Gene Model | MGI Sequence Detail 326383 C57BL/6J ±  kb
transcript OTTMUST00000123396 VEGA | MGI Sequence Detail 3632 Not Applicable 
polypeptide OTTMUSP00000067402 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1925 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1927)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
Protein Ontology PR:000006599 delta and Notch-like epidermal growth factor-related receptor
References
(Earliest) J:77803 Eiraku M, et al., Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem. 2002 Jul 12;277(28):25400-7
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(40)
Other
accession IDs
MGI:2444360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory