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Dner Gene Detail
Summary
  • Symbol
    Dner
  • Name
    delta/notch-like EGF repeat containing
  • Synonyms
    A930026D19Rik, BET, MGC:39059
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152889
    NCBI Gene: 227325
  • Gene Overview
    MyGene.info: DNER
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:84369839-84696221 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1921 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152889
protein coding gene Chr1:84369839-84696221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016227
protein coding gene Chr1:85404887-85732401 (-)
A/J MGP_AJ_G0016210
protein coding gene Chr1:82332284-82646239 (-)
AKR/J MGP_AKRJ_G0016167
protein coding gene Chr1:84590851-84914977 (-)
BALB/cJ MGP_BALBcJ_G0016165
protein coding gene Chr1:82473776-82793714 (-)
C3H/HeJ MGP_C3HHeJ_G0015995
protein coding gene Chr1:84974646-85300484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016618
protein coding gene Chr1:88688644-89008374 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014338
protein coding gene Chr1:77451046-77753094 (-)
CAST/EiJ MGP_CASTEiJ_G0015580
protein coding gene Chr1:84384159-84711962 (-)
CBA/J MGP_CBAJ_G0015969
protein coding gene Chr1:91527435-91874115 (-)
DBA/2J MGP_DBA2J_G0016070
protein coding gene Chr1:81624615-81950453 (-)
FVB/NJ MGP_FVBNJ_G0016073
protein coding gene Chr1:80709745-81032109 (-)
LP/J MGP_LPJ_G0016143
protein coding gene Chr1:86465942-86790717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016093
protein coding gene Chr1:94892960-95231760 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016665
protein coding gene Chr1:84747376-85091766 (-)
PWK/PhJ MGP_PWKPhJ_G0015366
protein coding gene Chr1:81042955-81351666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015144
protein coding gene Chr1:83944795-84276593 (-)
WSB/EiJ MGP_WSBEiJ_G0015641
protein coding gene Chr1:84540945-84864389 (-)



Homology
more
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bet, UNQ26
  • Links
    NCBI Gene ID: 92737
    neXtProt AC: NX_Q8NFT8
    UniProt: Q8NFT8

  • Chr Location
    2q36.3; chr2:229357629-229714570 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 26722
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DNER
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display delayed cerebellar development, abnormal Bergmann glial cells, abnormal Purkinje cell innervation, and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227325 NCBI Gene Model | MGI Sequence Detail 326383 C57BL/6J ±  kb
    transcript NM_152915 RefSeq | MGI Sequence Detail 3664 Not Specified  
    polypeptide Q8JZM4 UniProt | EBI | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006599 delta and Notch-like epidermal growth factor-related receptor
    • InterPro Domains
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2444360
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 14
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory