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Dner Gene Detail
Summary
  • Symbol
    Dner
  • Name
    delta/notch-like EGF repeat containing
  • Synonyms
    A930026D19Rik, BET, MGC:39059
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152889
    NCBI Gene: 227325
Location & Maps
more
  • Sequence Map
    Chr1:84369839-84696221 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      326383 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bet, UNQ26
  • Links
    NCBI Gene ID: 92737
    neXtProt AC: NX_Q8NFT8

  • Chr Location
    2q36.3; chr2:229357629-229714570 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 26722
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DNER
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Dner
  • Incidental Mutations
Homozygous null mice display delayed cerebellar development, abnormal Bergmann glial cells, abnormal Purkinje cell innervation, and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048002 VEGA Gene Model | MGI Sequence Detail 326383 C57BL/6J ±  kb
transcript OTTMUST00000123396 VEGA | MGI Sequence Detail 3632 Not Applicable  
polypeptide OTTMUSP00000067402 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1925 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006599 delta and Notch-like epidermal growth factor-related receptor
  • InterPro Domains
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain
Molecular
Reagents
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  • All nucleic 53
    cDNA 53

    Microarray probesets 7
Other
Accession IDs
less
MGI:2444360
References
more
  • Summaries
    All 38
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:77803 Eiraku M, et al., Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem. 2002 Jul 12;277(28):25400-7
  • Latest
    J:226616 Araujo DJ, et al., FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev. 2015 Oct 15;29(20):2081-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory