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Fbxl5
Gene Detail
 Symbol
Name
ID
Fbxl5
F-box and leucine-rich repeat protein 5
MGI:2152883
Synonyms Fbl4, Fir4
Feature Type protein coding gene
Genetic Map
Chromosome 5
23.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:43744616-43821639 bp, - strand
From VEGA annotation of GRCm38

  77024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: conserved protein with F-box/LRR-repeat, TIR1/COI1 type
Gene Tree: Fbxl5

Human
homologs
Human Homolog FBXL5, f-box and leucine-rich repeat protein 5
NCBI Gene ID 26234
neXtProt AC  NX_Q9UKA1
Human Synonyms  FBL4, FBL5, FLR1
Human Chr (Location)  4p15.32; chr4:15604384-15659867 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(2) Gene trapped(12) Radiation induced(1) Targeted(4)
Genomic Mutations involving Fbxl5 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality before turning of the embryo with iron overload, growth retardation, and hemorrhage. Mice heterozygous for a knock-out allele exhibit abnormal iron homeostasis when fed a low iron diet.
 
Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Fbxl5 interacts with 309 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process iron ion homeostasis, positive regulation of cellular protein catabolic process, ...
Component cytoplasm, perinuclear region of cytoplasm, ...
Function iron ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (78)    Tissues (30)    Images (13)
Theiler Stages: 2, 3, 19, 23, 28
Assay TypeResults
RNA in situ 42
RT-PCR 36
cDNA source data(98)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029016 (Evidence)
Ensembl Gene ModelENSMUSG00000039753 (Evidence)
Entrez Gene242960 (Evidence)
UniGene25794
DFCITC1571899, TC1585474, TC1604466, TC1776417
DoTSDT.101249641, DT.101295373, DT.111184838, DT.490912, DT.91307921, DT.94247403
NIA Mouse Gene IndexU026155
Consensus CDS ProjectCCDS19263.1, CCDS51489.1
International Mouse Knockout Project StatusFbxl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029016 VEGA Gene Model | MGI Sequence Detail 77024 C57BL/6J ±  kb
transcript OTTMUST00000071988 VEGA | MGI Sequence Detail 2857 Not Applicable 
polypeptide OTTMUSP00000036968 VEGA | MGI Sequence Detail 690 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(436 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR012312 Haemerythrin/HHE cation-binding motif
Protein Ontology PR:000007383 F-box/LRR-repeat protein 5
References (Earliest) J:72229 Hurle B, et al., Physical Mapping of the Mouse Tilted Locus Identifies an Association between Human Deafness Loci DFNA6/14 and Vestibular System Development. Genomics. 2001 Oct;77(3):189-99
(Latest) J:193752 Ruiz JC, et al., F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. J Biol Chem. 2013 Jan 4;288(1):552-60
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory