Asb7 MGI Mouse Gene Detail - MGI:2152835 - ankyrin repeat and SOCS box-containing 7

Symbol

Asb7
Name

ankyrin repeat and SOCS box-containing 7
Synonyms

Asb-7, D030055C23Rik

Feature Type

protein coding gene
IDs

MGI:2152835
NCBI Gene: 117589
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:66294313-66339344 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 36.03 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152835	protein coding gene	Chr7:66294220-66339601 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032353	protein coding gene	Chr7:67877071-67922860 (-)
A/J	MGP_AJ_G0032332	protein coding gene	Chr7:66482083-66527087 (-)
AKR/J	MGP_AKRJ_G0032268	protein coding gene	Chr7:67897863-67942861 (-)
BALB/cJ	MGP_BALBcJ_G0032344	protein coding gene	Chr7:66222113-66267464 (-)
C3H/HeJ	MGP_C3HHeJ_G0032057	protein coding gene	Chr7:68568653-68613780 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032836	protein coding gene	Chr7:70788704-70835206 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029843	protein coding gene	Chr7:69376809-69422534 (-)
CAST/EiJ	MGP_CASTEiJ_G0031385	protein coding gene	Chr7:59250959-59295883 (-)
CBA/J	MGP_CBAJ_G0032023	protein coding gene	Chr7:73005555-73050566 (-)
DBA/2J	MGP_DBA2J_G0032178	protein coding gene	Chr7:65203793-65248692 (-)
FVB/NJ	MGP_FVBNJ_G0032133	protein coding gene	Chr7:65330278-65375151 (-)
LP/J	MGP_LPJ_G0032259	protein coding gene	Chr7:69095090-69139980 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032170	protein coding gene	Chr7:73245885-73290921 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032854	protein coding gene	Chr7:67250591-67295745 (-)
PWK/PhJ	MGP_PWKPhJ_G0031105	protein coding gene	Chr7:58245568-58290642 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030946	protein coding gene	Chr7:54290770-54335774 (-)
WSB/EiJ	MGP_WSBEiJ_G0031503	protein coding gene	Chr7:67596006-67640950 (-)

Human Ortholog

ASB7, ankyrin repeat and SOCS box containing 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASB7, ankyrin repeat and SOCS box containing 7
Links

HGNC:17182

NCBI Gene ID: 140460

neXtProt AC: NX_Q9H672

UniProt: Q9H672
Chr Location

chr15:100602550-100651701 (+) GRCh38.p7

Alliance of Genome Resources

Asb7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASB7
Gene Tree

Asb7

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Asb7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asb7

ZFIN asb7

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Asb7 interacts with 364 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS21346.1

Ensembl

ENSMUSG00000030509 (Evidence)
NCBI Gene

117589

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030509	Ensembl Gene Model \| MGI Sequence Detail	45032	C57BL/6J	± kb
transcript	ENSMUST00000124899	Ensembl \| MGI Sequence Detail	4928	Not Applicable
polypeptide	ENSMUSP00000122395	Ensembl \| MGI Sequence Detail	318	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004356 ankyrin repeat and SOCS box protein 7

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR037326 Ankyrin repeat and SOCS box protein 7, SOCS box domain

IPR036770 Ankyrin repeat-containing domain superfamily

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

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All nucleic 12

cDNA 12

Microarray probesets 8

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MGI:2141960, MGI:2441936

Summaries

All 37

Gene Ontology 1

Phenotypes 13
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:321561 Liu Y, et al., ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. Front Cell Dev Biol. 2020;8:595917

TSS for Asb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72828	Chr7:66339361-66339372 (-)	-23 bp
Tssr72827	Chr7:66339337-66339351 (-)	0 bp
Tssr72826	Chr7:66339299-66339317 (-)	36 bp
Tssr72825	Chr7:66339248-66339273 (-)	83 bp
Tssr72824	Chr7:66339222-66339239 (-)	113 bp
Tssr72823	Chr7:66334042-66334047 (-)	5,299 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20