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Creld1 Gene Detail
Summary
  • Symbol
    Creld1
  • Name
    cysteine-rich with EGF-like domains 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152539
    NCBI Gene: 171508
  • Gene Overview
    MyGene.info: CRELD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:113483297-113493343 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.77 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CRELD1, cysteine rich with EGF like domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRELD1, cysteine rich with EGF like domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AVSD2, CIRRIN
  • Links
    NCBI Gene ID: 78987
    neXtProt AC: NX_Q96HD1
    UniProt: Q96HD1

  • Chr Location
    3p25.3; chr3:9933788-9945413 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32265
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRELD1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CRELD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO is embryonic lethal: abnormal vasculature and brain and craniofacial development and reduced atrioventricular cushion size at E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023299 VEGA Gene Model | MGI Sequence Detail 10047 C57BL/6J ±  kb
    transcript OTTMUST00000056426 VEGA | MGI Sequence Detail 2306 Not Applicable  
    polypeptide OTTMUSP00000027118 VEGA | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      62 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141490
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:78392 Rupp PA, et al., Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. Gene. 2002 Jun 26;293(1-2):47-57
    • Latest
      J:242434 Li H, et al., Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier. Genetics. 2016 Jun;203(2):763-70

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory