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Creld1 Gene Detail
Summary
  • Symbol
    Creld1
  • Name
    cysteine-rich with EGF-like domains 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152539
    NCBI Gene: 171508
  • Gene Overview
    MyGene.info: CRELD1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113483297-113493343 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152539
protein coding gene Chr6:113483295-113493343 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031127
protein coding gene Chr6:116006206-116016149 (+)
A/J MGP_AJ_G0031096
protein coding gene Chr6:111560351-111570387 (+)
AKR/J MGP_AKRJ_G0031027
protein coding gene Chr6:114554218-114563951 (+)
BALB/cJ MGP_BALBcJ_G0031107
protein coding gene Chr6:111506375-111516447 (+)
C3H/HeJ MGP_C3HHeJ_G0030601
protein coding gene Chr6:69732483-69742527 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031566
protein coding gene Chr6:119008979-119019041 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028730
protein coding gene Chr6:108588272-108597817 (+)
CAST/EiJ MGP_CASTEiJ_G0030214
protein coding gene Chr6:115000193-115011936 (+)
CBA/J MGP_CBAJ_G0030793
protein coding gene Chr6:123703207-123713246 (+)
DBA/2J MGP_DBA2J_G0030946
protein coding gene Chr6:110639720-110649771 (+)
FVB/NJ MGP_FVBNJ_G0030900
protein coding gene Chr6:109641824-109651838 (+)
LP/J MGP_LPJ_G0031026
protein coding gene Chr6:116040065-116050124 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030934
protein coding gene Chr6:127967616-127981087 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031593
protein coding gene Chr6:114568549-114579241 (+)
PWK/PhJ MGP_PWKPhJ_G0029930
protein coding gene Chr6:109596084-109606421 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029758
protein coding gene Chr6:113387115-113397109 (+)
WSB/EiJ MGP_WSBEiJ_G0030298
protein coding gene Chr6:114943175-114954519 (+)



Homology
more
  • Human Ortholog
    CRELD1, cysteine rich with EGF like domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRELD1, cysteine rich with EGF like domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AVSD2, CIRRIN
  • Links
    NCBI Gene ID: 78987
    neXtProt AC: NX_Q96HD1
    UniProt: Q96HD1

  • Chr Location
    3p25.3; chr3:9933788-9945413 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32265
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRELD1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CRELD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO is embryonic lethal: abnormal vasculature and brain and craniofacial development and reduced atrioventricular cushion size at E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030284 Ensembl Gene Model | MGI Sequence Detail 10047 C57BL/6J ±  kb
    transcript ENSMUST00000032422 Ensembl | MGI Sequence Detail 2306 Not Applicable  
    polypeptide ENSMUSP00000032422 Ensembl | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141490
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:78392 Rupp PA, et al., Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. Gene. 2002 Jun 26;293(1-2):47-57
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory